CT Perfusion evaluation of gastric cancer: correlation with histologic type
- 569 Downloads
To prospectively evaluate if the perfusion parameters of gastric cancer can provide information on histologic subtypes of gastric cancer.
We performed preoperative perfusion CT (PCT) and curative gastrectomy in 46 patients. PCT data were analysed using a dedicated software program. Perfusion parameters were obtained by two independent radiologists and were compared according to histologic type using Kruskal–Wallis, Mann–Whitney U test and receiver operating characteristic analysis. To assess inter-reader agreement, we used intraclass correlation coefficient (ICC).
Inter-reader agreement for perfusion parameters was moderate to substantial (ICC = 0.585–0.678). Permeability surface value of poorly cohesive carcinoma (PCC) was significantly higher than other histologic types (47.3 ml/100 g/min in PCC vs 26.5 ml/100 g/min in non-PCC, P < 0.001). Mean transit time (MTT) of PCC was also significantly longer than non-PCC (13.0 s in PCC vs 10.3 s in non-PCC, P = 0.032). The area under the curve to predict PCC was 0.891 (P < 0.001) for permeability surface and 0.697 (P = 0.015) for MTT.
Obtaining perfusion parameters from PCT was feasible in gastric cancer patients and can aid in the preoperative imaging diagnosis of PCC-type gastric cancer as the permeability surface and MTT value of PCC type gastric cancer were significantly higher than those of non-PCC.
• Obtaining perfusion parameters from PCT was feasible in patients with gastric cancer.
• Permeability surface and MTT were significantly higher in poorly cohesive carcinoma (PCC).
• Permeability surface, MTT can aid in the preoperative imaging diagnosis of PCC.
KeywordsHistologic type of gastric cancer Perfusion CT Poorly cohesive carcinoma Permeability surface Mean transit time
Compliance with ethical standards
The scientific guarantor of this publication is Se Hyung Kim.
Conflict of interest
The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article.
The authors state that this study was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT& Future Planning (NRF-2016R1A2B4007762) and by Seoul National University Hospital Research Fund No. 04-2015-620.
Statistics and biometry
No complex statistical methods were necessary for this paper.
Institutional review board approval was obtained.
Written informed consent was obtained from all patients in this study.
• performed at one institution
- 23.Bang YJ, Van Cutsem E, Feyereislova A et al (2010) Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial. Lancet 376:687–697CrossRefPubMedGoogle Scholar