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European Radiology

, Volume 27, Issue 12, pp 5225–5235 | Cite as

Preoperative staging of endometrial cancer using reduced field-of-view diffusion-weighted imaging: a preliminary study

  • Takashi Ota
  • Masatoshi Hori
  • Hiromitsu Onishi
  • Makoto Sakane
  • Takahiro Tsuboyama
  • Mitsuaki Tatsumi
  • Atsushi Nakamoto
  • Tadashi Kimura
  • Yoshifumi Narumi
  • Noriyuki Tomiyama
Urogenital

Abstract

Objectives

To compare the image quality and diagnostic performance of reduced field-of-view (rFOV) versus conventional full field-of-view (fFOV) diffusion-weighted (DW) imaging of endometrial cancer.

Methods

Fifty women with endometrial cancer underwent preoperative rFOV and fFOV DW imaging. Two radiologists compared the image qualities of both techniques, and five radiologists assessed superficial and deep myometrial invasion using both techniques. The statistical analysis included the Wilcoxon signed-rank test and paired t-test for comparisons of image quality and mean diagnostic values.

Results

Distortion, tumour delineation, and overall image quality were significantly better with rFOV DW imaging, compared to fFOV DW imaging (P < 0.05); however, the former was inferior in noise (P < 0.05). Regarding superficial invasion, the mean accuracies of the techniques did not differ statistically (rFOV, 58.0% versus fFOV, 56.0%; P = 0.30). Regarding deep myometrial invasion, rFOV DW imaging yielded significantly better mean accuracy, specificity, and positive predictive values (88.4%, 97.8%, and 91.7%, respectively), compared with fFOV DW imaging (84.8%, 94.1%, and 77.4%, respectively; P = 0.009, 0.005, and 0.011, respectively).

Conclusions

Compared with fFOV DW imaging, rFOV DW imaging yielded less distortion, improved image quality and, consequently, better diagnostic performance for deep myometrial invasion of endometrial cancer.

Key Points

rFOV DWI yields better assessment of deep myometrial invasion in endometrial cancer.

rFOV DWI could not sufficiently evaluate superficial invasion in endometrial cancer.

Distortion, tumour delineation, and overall image quality were improved with rFOV DWI.

Keywords

Magnetic resonance imaging Diffusion-weighted Uterine neoplasms Endometrial neoplasms Neoplasm staging 

Abbreviations

DW

diffusion-weighted

EPI

echo-planar imaging

rFOV DW

reduced field-of-view diffusion-weighted

fFOV DW

full field-of-view diffusion-weighted

rFOV DW/T2-Weighted Imaging

reduced field-of-view diffusion-weighted imaging and T2-weighted imaging

fFOV DW/T2-Weighted Imaging

full field-of-view diffusion-weighted imaging and T2-weighted imaging

ADC

apparent diffusion coefficient

Notes

Acknowledgements

The authors thank Enago (www.enago.jp) for the English language review. Yumiko Hori (Department of Pathology, Osaka University Graduate School of Medicine) kindly provided histopathological image for this study.

Compliance with ethical standards

Guarantor

The scientific guarantor of this publication is Masatoshi Hori.

Conflict of interest

The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.

Funding

The authors state that this work has not received any funding.

Statistics and biometry

One of the authors has significant statistical expertise.

Informed consent

Written informed consent was waived by the Institutional Review Board.

Ethical approval

Institutional Review Board approval was obtained.

Methodology

• retrospective

• diagnostic or prognostic study

• performed at one institution

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Copyright information

© European Society of Radiology 2017

Authors and Affiliations

  • Takashi Ota
    • 1
  • Masatoshi Hori
    • 1
  • Hiromitsu Onishi
    • 1
  • Makoto Sakane
    • 1
  • Takahiro Tsuboyama
    • 1
  • Mitsuaki Tatsumi
    • 1
  • Atsushi Nakamoto
    • 2
  • Tadashi Kimura
    • 3
  • Yoshifumi Narumi
    • 2
  • Noriyuki Tomiyama
    • 1
  1. 1.Department of Diagnostic and Interventional RadiologyOsaka University Graduate School of MedicineSuitaJapan
  2. 2.Department of RadiologyOsaka Medical CollegeOsakaJapan
  3. 3.Department of Obstetrics and GynaecologyOsaka University Graduate School of MedicineOsakaJapan

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