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European Radiology

, Volume 27, Issue 12, pp 5290–5298 | Cite as

Prostate-specific membrane antigen PET/MRI validation of MR textural analysis for detection of transition zone prostate cancer

Magnetic Resonance

Abstract

Objectives

To validate MR textural analysis (MRTA) for detection of transition zone (TZ) prostate cancer through comparison with co-registered prostate-specific membrane antigen (PSMA) PET-MR.

Methods

Retrospective analysis was performed for 30 men who underwent simultaneous PSMA PET-MR imaging for staging of prostate cancer. Thirty texture features were derived from each manually contoured T2-weighted, transaxial, prostatic TZ using texture analysis software that applies a spatial band-pass filter and quantifies texture through histogram analysis. Texture features of the TZ were compared to PSMA expression on the corresponding PET images. The Benjamini-Hochberg correction controlled the false discovery rate at <5%.

Results

Eighty-eight T2-weighted images in 18 patients demonstrated abnormal PSMA expression within the TZ on PET-MR. 123 images were PSMA negative. Based on the corrected p-value of 0.005, significant differences between PSMA positive and negative slices were found for 16 texture parameters: Standard deviation and mean of positive pixels for all spatial filters (p = <0.0001 for both at all spatial scaling factor (SSF) values) and mean intensity following filtration for SSF 3–6 mm (p = 0.0002–0.0018).

Conclusion

Abnormal expression of PSMA within the TZ is associated with altered texture on T2-weighted MR, providing validation of MRTA for the detection of TZ prostate cancer.

Key Points

• Prostate transition zone (TZ) MR texture analysis may assist in prostate cancer detection.

• Abnormal transition zone PSMA expression correlates with altered texture on T2-weighted MR.

• TZ with abnormal PSMA expression demonstrates significantly reduced MI, SD and MPP.

Keywords

Magnetic resonance imaging Texture analysis Prostate Cancer Diagnosis 

Abbreviations

AUC

Area under the receiver-operating characteristic curve

DRE

Digital rectal exam

GS

Gleason score

HASTE

Half-Fourier acquisition single-shot turbo spin echo imaging

MI

Mean intensity

mp-MRI

Multiparametric MRI

MPP

Mean of positive pixels

MRTA

MRI textural analysis

PSMA

Prostate-specific membrane antigen

PZ

Peripheral zone of the prostate

SD

Standard deviation

SSF

Spatial scaling factor

TRUS

Transrectal ultrasound

TZ

Transition zone of the prostate

Notes

Compliance with ethical standards

Guarantor

The scientific guarantor of this publication is Professor Kenneth Miles.

Conflict of interest

The authors of this manuscript declare relationships with the following companies: Professor Kenneth Miles is one of the shareholders of the textural analysis software, TexRad (Feedback PLC, Cambridge, UK).

Funding

The authors state that this work has not received any funding.

Statistics and biometry

Professor Kenneth Miles has significant statistical expertise.

Informed consent

Written informed consent was waived by the Institutional Review Board.

Ethical approval

Institutional Review Board approval was obtained.

Methodology

• retrospective

• observational study

• performed at one institution

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Copyright information

© European Society of Radiology 2017

Authors and Affiliations

  1. 1.Princess Alexandra HospitalBrisbaneAustralia
  2. 2.MoorookaAustralia
  3. 3.Department of Diagnostic RadiologyPrincess Alexandra HospitalBrisbaneAustralia
  4. 4.Institute of Nuclear MedicineUniversity College LondonLondonUK

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