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European Radiology

, Volume 27, Issue 10, pp 4037–4043 | Cite as

CT and histopathologic characteristics of lung adenocarcinoma with pure ground-glass nodules 10 mm or less in diameter

  • Fang Wu
  • Shu-ping Tian
  • Xin Jin
  • Rui Jing
  • Yue-qing Yang
  • Mei Jin
  • Shao-hong ZhaoEmail author
Chest

Abstract

Objective

To evaluate CT and histopathologic features of lung adenocarcinoma with pure ground-glass nodule (pGGN) ≤10 mm in diameter.

Methods

CT appearances of 148 patients (150 lesions) who underwent curative resection of lung adenocarcinoma with pGGN ≤10 mm (25 atypical adenomatous hyperplasias, 42 adenocarcinoma in situs, 38 minimally invasive adenocarcinomas, and 45 invasive pulmonary adenocarcinomas) were analyzed for lesion size, density, bubble-like sign, air bronchogram, vessel changes, margin, and tumour-lung interface. CT characteristics were compared among different histopathologic subtypes. Univariate and multivariate analysis were used to assess the relationship between CT characteristics of pGGN and lesion invasiveness, respectively.

Results

There were statistically significant differences among histopathologic subtypes in lesion size, vessel changes, and tumour-lung interface (P<0.05). Univariate analysis revealed significant differences of vessel changes, margin and tumour-lung interface between preinvasive and invasive lesions (P<0.05). Logistic regression analysis showed that the vessel changes, unsmooth margin and clear tumour-lung interface were significant predictive factors for lesion invasiveness, with odds ratios (95% CI) of 2.57 (1.17-5.62), 1.83 (1.25-2.68) and 4.25 (1.78-10.14), respectively.

Conclusion

Invasive lesions are found in 55.3% of subcentimeter pGGNs in our cohort. Vessel changes, unsmooth margin, and clear lung-tumour interface may indicate the invasiveness of lung adenocarcinoma with subcentimeter pGGN.

Key points

• Invasive lesions were found in 55.3% of lung adenocarcinomas with subcentimeter pGGNs

• Lesion size, vessel changes, and tumour-lung interface showed different among histopathologic subtypes

• Vessel changes, unsmooth margin and clear tumour-lung interface were predictors for lesion invasiveness

Keywords

Ground-glass nodule Lung neoplasms Adenocarcinoma Histopathology Tomography, X-ray computed 

Abbreviations

CT

Computed tomography

pGGN

Pure ground-glass nodule

AAH

Atypical adenomatous hyperplasia

AIS

Adenocarcinoma in situ

MIA

Minimally invasive adenocarcinoma

IPA

Invasive pulmonary adenocarcinoma

HU

Hounsfield unit

ANOVA

One-way analysis of variance

SNK

Student-Newman-Keuls

IASLC

International Association for the Study of Lung Cancer

ATS

American Thoracic Society

ERS

European Respiratory Society

Notes

Compliance with ethical standards

Guarantor

The scientific guarantor of this publication is Dr. Shaohong Zhao.

Conflict of interest

The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.

Funding

The authors state that this work has not received any funding.

Statistics and biometry

No complex statistical methods were necessary for this paper.

Ethical approval

Institutional Review Board approval was required.

Informed consent

Written informed consent was required for this study.

Methodology

• retrospective

• diagnostic or prognostic study

• performed at one institution

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Copyright information

© European Society of Radiology 2017

Authors and Affiliations

  • Fang Wu
    • 1
    • 2
  • Shu-ping Tian
    • 3
  • Xin Jin
    • 1
  • Rui Jing
    • 1
  • Yue-qing Yang
    • 1
  • Mei Jin
    • 1
  • Shao-hong Zhao
    • 1
    Email author
  1. 1.Department of RadiologyChinese PLA General HospitalBeijingChina
  2. 2.Department of Radiology, Xuanwu HospitalCapital Medical UniversityBeijingChina
  3. 3.Department of RadiologyNavy General HospitalBeijingChina

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