Abstract
Objective
To assess the utility of the motion correction method with prospective motion correction (PROMO) in a voxel-based morphometry (VBM) analysis for ‘uncooperative’ patient populations.
Methods
High-resolution 3D T1-weighted imaging both with and without PROMO were performed in 33 uncooperative patients with Parkinson's disease (n = 11) or dementia (n = 22). We compared the grey matter (GM) volumes and cortical thickness between the scans with and without PROMO.
Results
For the mean total GM volume with the VBM analysis, the scan without PROMO showed a significantly smaller volume than that with PROMO (p < 0.05), which was caused by segmentation problems due to motion during acquisition. The whole-brain VBM analysis showed significant GM volume reductions in some regions in the scans without PROMO (familywise error corrected p < 0.05). In the cortical thickness analysis, the scans without PROMO also showed decreased cortical thickness compared to the scan with PROMO (p < 0.05).
Conclusion
Our results with the uncooperative patients indicate that the use of PROMO can reduce misclassification during segmentation of the VBM analyses, although it may not prevent GM volume reduction.
Key Points
• Motion artifacts pose significant problems for VBM analyses.
• PROMO correction can reduce the motion artifacts in high-resolution 3D T1WI.
• The use of PROMO may improve the precision of VBM analyses.
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Abbreviations
- EKF:
-
Extended Kalman filter
- GM:
-
Grey matter
- MPRAGE:
-
Magnetization-prepared Rapid Acquisition Gradient Echo
- PROMO:
-
Prospective motion correction
- T1WI:
-
T1-weighted imaging
- VBM:
-
Voxel-based morphometry
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Acknowledgements
This work was technically supported by Scientific Research on Innovative Areas (Comprehensive Brain Science Network) from the Ministry of Education, Science, Sports and Culture of Japan.
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The scientific guarantor of this publication is Yukunori Korogi.
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The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article.
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The authors state that this work has not received any funding.
Statistics and biometry
No complex statistical methods were necessary for this paper.
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Institutional Review Board approval was obtained.
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Written informed consent was obtained from all subjects (patients) in this study.
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Any study subjects or cohorts have not been previously reported.
Methodology
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prospective
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observation
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performed at one institution
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Igata, N., Kakeda, S., Watanabe, K. et al. Utility of real-time prospective motion correction (PROMO) for segmentation of cerebral cortex on 3D T1-weighted imaging: Voxel-based morphometry analysis for uncooperative patients. Eur Radiol 27, 3554–3562 (2017). https://doi.org/10.1007/s00330-016-4730-7
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DOI: https://doi.org/10.1007/s00330-016-4730-7