Prognostic relevance of gemistocytic grade II astrocytoma: gemistocytic component and MR imaging features compared to non-gemistocytic grade II astrocytoma
- 260 Downloads
To determine if gemistocytic grade II astrocytoma (GemA) and its MR imaging characteristics are associated with a shorter time-to-progression (TTP) compared with non-gemistocytic grade II astrocytoma (non-GemA).
Materials and methods
We enrolled 78 patients who were followed up more than 5 years (29 pathologically proven GemA and 49 non-GemA) during a 10-year period. Contrast-enhanced T1-weighted, diffusion-weighted imaging (DWI), dynamic susceptibility contrast (DSC), and MR spectroscopy (MRS) and clinical data were retrospectively reviewed. Clinical and MR imaging features were analyzed as possible prognostic factors of high-grade transformation, and multivariate analysis of TTP was performed using Cox proportional modeling.
GemA showed more frequent high-grade features than non-GemA, including diffusion restriction (P < .001), increased choline/creatine (P = .02), and increased choline/NAA ratio (P = .015). Patients with GemA had a significantly shorter median TTP (53.1 vs 68 months; P < .001). A gemistocytic histopathology (hazard ratio = 3.42; P = .015) and low ADC (hazard ratio = 3.61; P = .001) were independently associated with a shorter TTP.
GemA can present with MR imaging findings mimicking high-grade glioma at initial diagnosis and transforms to high-grade disease earlier than non-GemA. Low ADC on DWI might be useful in stratifying the risk of progression in patients with grade II astrocytoma.
• Gemistocytic grade II astrocytoma (GemA) showed more frequent high-grade features than non-GemA.
• Patients with GemA had a significantly shorter median TTP than non-GemA.
• Gemistocytic histopathology and low ADC were independently associated with shorter TTP.
KeywordsAstrocytoma Grade II Gemistocytic astrocytoma Disease progression Diffusion magnetic resonance imaging
Gemistocytic low-grade astrocytoma
Non-gemistocytic low-grade astrocytoma
Dynamic susceptibility contrast
Apparent diffusion coefficient
Normalized cerebral blood volume
The scientific guarantor of this publication is Sang Joon Kim. The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article. This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (grant number: NRF-2014R1A2A2A01004937). No complex statistical methods were necessary for this paper. Institutional Review Board approval was obtained. Written informed consent was waived by the Institutional Review Board. Methodology: retrospective, observational study, performed at one institution.
- 8.Russel D, Rubinstein L (1989) Pathology of tumours of the central nervous systemGoogle Scholar
- 11.Togao O, Hiwatashi A, Yamashita K et al (2016) Grading diffuse gliomas without intense contrast enhancement by amide proton transfer MR imaging: comparisons with diffusion- and perfusion-weighted imaging. Eur RadiolGoogle Scholar
- 24.Xiao HF, Chen ZY, Lou X et al (2015) Astrocytic tumour grading: a comparative study of three-dimensional pseudocontinuous arterial spin labelling, dynamic susceptibility contrast-enhanced perfusion-weighted imaging, and diffusion-weighted imaging. Eur Radiol 25:3423–3430CrossRefPubMedPubMedCentralGoogle Scholar