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Diffusion-weighted MR enterography for evaluating Crohn’s disease: Effect of anti-peristaltic agent on the diagnosis of bowel inflammation

  • Gastrointestinal
  • Published:
European Radiology Aims and scope Submit manuscript

Abstract

Objectives

To prospectively investigate how Buscopan affects the diagnosis of bowel inflammation by diffusion-weighted imaging MR enterography (DWI-MRE) in Crohn’s disease (CD).

Methods

Thirty CD patients without previous bowel surgery underwent DWI-MRE (b = 900 sec/mm2) before and after intravenous Buscopan. The 30 patients were randomly divided into two groups; using a crossover design, interpretations were made regarding the presence of restricted mural diffusion (i.e., bowel inflammation) in nine bowel segments in two separate reading sessions by two readers. The readers also judged restricted mural diffusion extent in each bowel segment on two side-by-side DWI-MRE images with a random right-to-left order. Ileocolonoscopy and conventional MRE interpreted by an expert panel were reference standards.

Results

We analyzed 262 bowel segments. DWI-MRE without Buscopan significantly decreased sensitivity for both readers (58.8 % vs. 72.9 %, P = 0.046; 57.6 % vs. 85.9 %, P = 0.001) and did not significantly increase specificity (P = 0.085 and 0.396). Two readers noted that 28.6 % and 23.3 % of 262 bowel segments had greater diffusion restriction extent on DWI-MRE with Buscopan compared with DWI-MRE without Buscopan (P < 0.001) and 68.7 % and 74 %, respectively, had similar extent between them.

Conclusion

Omitting Buscopan caused a greater loss in sensitivity of DWI-MRE than false-positive reduction for diagnosing bowel inflammation in CD.

Key Points

• Omitting Buscopan significantly decreases DWI-MRE sensitivity for diagnosing bowel inflammation in CD.

• Increase in the corresponding DWI-MRE specificity by omitting Buscopan is less apparent.

• DWI-MRE without Buscopan underestimates the extent of bowel inflammation in CD.

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Abbreviations

DWI:

diffusion-weighted imaging

MRE:

MR enterography

CD:

Crohn’s disease

ADC:

apparent diffusion coefficient

CDAI:

Crohn’s disease activity index

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Acknowledgments

The scientific guarantor of this publication is Dr. Seong Ho Park. The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article. The authors state that this work has not received any funding. Seong Ho Park, MD, PhD, who is one of the authors, has significant statistical expertise and provided statistical advice for this manuscript. Institutional Review Board of Asan Medical Center approval was obtained. Written informed consent was obtained from all subjects (patients) in this study. No study subjects or cohorts have been previously reported. Methodology: prospective, diagnostic or prognostic study, performed at one institution.

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Author notes

  1. So Hyun Park

    Present address: Department of Radiology, Gil Medical Center, Gachon University, 21, Namdong-daero 777beon-gil, Namdong-gu, Incheon, South Korea

Authors and Affiliations

  1. Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South Korea

    So Hyun Park, Jimi Huh, Seong Ho Park, Seung Soo Lee & Ah Young Kim

  2. Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South Korea

    Suk-Kyun Yang

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  1. So Hyun Park
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Corresponding author

Correspondence to Seong Ho Park.

Additional information

So Hyun Park and Jimi Huh contributed equally to this work.

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Park, S.H., Huh, J., Park, S.H. et al. Diffusion-weighted MR enterography for evaluating Crohn’s disease: Effect of anti-peristaltic agent on the diagnosis of bowel inflammation. Eur Radiol 27, 2554–2562 (2017). https://doi.org/10.1007/s00330-016-4609-7

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  • DOI: https://doi.org/10.1007/s00330-016-4609-7

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