Abstract
Objectives
To assess the treatment-induced changes of health-related quality-of-life (HRQoL) in patients with venous malformations (VM) who underwent ethanol gel sclerotherapy.
Methods
The prospective study in children and adults was approved by the local ethics committee. 31 patients (mean age 23.42 years, range 6.6 – 46.5; 26 female, 5 male) with VM were included. Patients’ self-assessed HRQoL was measured before and after treatment using psychometrically validated questionnaires for adults and children. Differences were analysed with a paired t test.
Results
58 sclerotherapy sessions were performed. The Physical Component Summary (PCS) at baseline was 43.69 and increased significantly (p = 0.01122) to 48.95 after treatment. The bodily pain (BP) scale increased significantly from 37.94 to 48.56 (p = 0.00002), the general health (GH) scale increased significantly from 46.69 to 52.17 (p = 0.00609). Baseline Physical Summary Score (PHS) in children increased significantly after treatment (p < 0.00001) from 25.25 to 45.89. The baseline Psychosocial Summary Score (PSS) in children was 51.08 and increased significantly (p = 0.00031) after treatment to 58.84.
Conclusion
Paediatric and adult patients with VM suffer from bodily pain with overall reduced physical functioning. After sclerotherapy, these restrictions are successfully returning to normal levels with a positive effect on mental and psychosocial domains.
Key points
• Sclerotherapy in venous malformation patients has an unknown effect on health-related quality-of-life
• Prospective study showed improvements in bodily pain and general health in adults
• Children and adults improved from treatment with ethanol gel
• Sclerotherapy is an appropriate therapy
Similar content being viewed by others
References
Wassef M, Blei F, Adams D, Alomari A, Baselga E, Berenstein A et al (2015) Vascular anomalies classification: recommendations from the International Society for the Study of Vascular Anomalies. Pediatrics 136:e203–e214
Vogel SA, Hess CP, Dowd CF, Hoffman WY, Kane AJ, Rajaii R et al (2013) Early versus later presentations of venous malformations: where and why? Pediatr Dermatol 30:534–540
Lee BB, Baumgartner I, Berlien P, Bianchini G, Burrows P, Gloviczki P et al (2015) Diagnosis and treatment of venous malformations. Consensus document of the International Union of Phlebology (IUP): updated 2013. Int Angiol 34:97–149
Norgren L, Hiatt WR, Dormandy JA, Nehler MR, Harris KA, Fowkes FG et al (2007) Inter-society consensus for the management of peripheral arterial disease (TASC II). J Vasc Surg 45:S5–S67
Schumacher M, Dupuy P, Bartoli JM, Ernemann U, Herbreteau D, Ghienne C et al (2011) Treatment of venous malformations: first experience with a new sclerosing agent–a multicenter study. Eur J Radiol 80:e366–e372
Sannier K, Dompmartin A, Théron J, Labbé D, Barrellier MT, Leroyer R et al (2004) A new sclerosing agent in the treatment of venous malformations. study on 23 cases. Interv Neuroradiol 10:113–127
Saris-Baglama RN, Dewey CJ, Chisholm GB, Plumb E, King J, Rasicot P et al (2011) Quality metric health outcomes scoring software 4.5 – users guide. Quality Metric Inc. Lincoln
Ware JE Jr, Kosinski M, Dewey JE (2000) How to score version 2 of the SF-36® Health Survey. QualityMetric Inc, Lincoln
Landgraf JM, Abetz L, Ware JE (1996) The CHQ: a user's manual, 1st edn. The Health Institute, Boston
Taft C, Karlsson J, Sullivan M (2001) Do SF-36® summary component scores accurately summarize subscale scores? Qual Life Res 10:395–404
Balakrishnan K, Bauman N, Chun RH, Darrow DH, Grimmer JF, Perkins JA et al (2015) Standardized outcome and reporting measures in pediatric head and neck lymphatic malformations. Otolaryngol Head Neck Surg 152:948–953
Burrows PE, Mason KP (2004) Percutaneous treatment of low flow vascular malformations. J Vasc Interv Radiol 15:431–445
Weinstein JM, Chamlin SL (2005) Quality of life in vascular anomalies. Lymphat Res Biol 8:256–260
Van der Pleog HM, van der Ploeg MN, van der Ploeg-Stapert JD (1995) Psychological aspects of the Klippel-Trenaunay syndrome. J Psychosom Res 39:183–191
Boetes C, Boll AP, Hartman PH, van Oostrom CG, Rieu PN, de Rooij M et al (1997) Klippel-Trenaunay-type congenital angiodysplasia syndrome; medical and psychological aspects. Ned Tijdschr Geneeskd 141:650–651
Van der Linden E, Pattynama PM, Heeres BC, de Jong SC, Hop WC, Kroft LJ (2009) Long-term patient satisfaction after percutaneous treatment of peripheral vascular malformations. Radiology 251:926–932
Oduber CEU, Khemlani K, Smitt JHS, Hennekam RCM, van der Horst CMAM (2010) Baseline quality of life in patients with Klippel-Trenaunay syndrome. J Plast Reconstruct Aesthet Surg 63:603–609
Geirdal AØ, Dheyauldeen S, Bachmann-Harildstad G, Heimdal K (2012) Quality of life in patients with hereditary hemorrhagic telangiectasia in Norway: a population based study. Am J Med Genet A 158A:1269–1278
Breugem CC, Merkus MP, Smitt JH, Legemate DA, van der Horst CM (2004) Quality of life in patients with vascular malformations of the lower extremity. Br J Plast Surg 57:754–763
Rautio R, Laranne J, Kähärä V, Saarinen J, Keski-Nisula L (2004) Long-term results and quality of life after endovascular treatment of venous malformations in the face and neck. Acta Radiol 45:738–745
Rautio R, Saarinen J, Laranne J, Salenius JP, Keski-Nisula L (2004) Endovascular treatment of venous malformations in extremities: results of sclerotherapy and the quality of life after treatment. Acta Radiol 45:397–403
Ware JE Jr, Harris WJ, Gandek B, Rogers BW, Reese PR (1997) MAP-R for Windows: Multitrait/multi-item scale analysis software. Health Assessment Lab, Boston
Acknowledgments
The scientific guarantor of this publication is WAW. WAW, WU and RMW declare relationships with the following companies: ab medica, Düsseldorf, Germany (lecturing, proctoring). The authors state that this work has not received any funding. WAW has significant statistical expertise. Institutional review board approval from the Ethikkommission an der Universität Regensburg was obtained. Written informed consent was obtained from all subjects (patients) in this study. Methodology: prospective, longitudinal study, performed at one institution.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Wohlgemuth, W.A., Müller-Wille, R., Teusch, V. et al. Ethanolgel sclerotherapy of venous malformations improves health-related quality-of-life in adults and children – results of a prospective study. Eur Radiol 27, 2482–2488 (2017). https://doi.org/10.1007/s00330-016-4603-0
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00330-016-4603-0