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Altered intrinsic brain activity after chemotherapy in patients with gastric cancer: A preliminary study

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An Erratum to this article was published on 16 February 2017

Abstract

Objectives

To characterize the pattern of altered intrinsic brain activity in gastric cancer patients after chemotherapy (CTx).

Methods

Patients before and after CTx (n = 14) and control subjects (n = 11) underwent resting-state functional MRI (rsfMRI) at baseline and 3 months after CTx. Regional homogeneity (ReHo), amplitude of low-frequency fluctuation (ALFF), and fractional ALFF (fALFF) were calculated and compared between the groups using the two-sample t test. Correlation analysis was also performed between rsfMRI values (i.e., ReHo, ALFF, and fALFF) and neuropsychological test results.

Results

Patients showed poor performance in verbal memory and executive function and decreased rsfMRI values in the frontal areas even before CTx and showed decreased attention/working memory and executive function after CTx compared to the control subjects. In direct comparison of values before and after CTx, there were no significant differences in neuropsychological test scores, but decreased rsfMRI values were observed at the frontal lobes and right cerebellar region. Among rsfMRI values, lower ALFF in the left inferior frontal gyrus was significantly associated with poor performance of the executive function test.

Conclusions

We observed decreased attention/working memory and executive function that corresponded to the decline of frontal region activation in gastric cancer patients who underwent CTx.

Key Points

Intrinsic brain activity of gastric cancer patients after chemotherapy was described.

Brain activity and neuropsychological test results were correlated.

Working memory and executive function decreased after chemotherapy.

Decreased cognitive function corresponded to decreased activation of the frontal region.

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Acknowledgments

The scientific guarantor of this publication is Na-Young Shin. The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article. This work was supported by the Ewha Womans University Research Grant of 2015 (1-2015-0437-001-1). One of the authors has significant statistical expertise (Kyunghwa Han). Institutional review board approval was obtained. Written informed consent was obtained from all subjects (patients) in this study. Methodology: prospective, case-control study, performed at one institution.

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Correspondence to Na-Young Shin.

Additional information

The original version of this article was revised: The sentence, “Linear regression was estimated with six motion parameters, CSF signal, WM signal, and global mean as covariates to remove the head motion effect and other possible artefacts.” was deleted from the section on rsfMRI imaging preprocessing. Reason: We originally analyzed the data using the basic edition of DPARSF toolbox version 2.2 in which nuisance regression was not applied before calculating ALFF, fALFF and ReHo, but regression could be performed at a later date for preprocessing with the updated version of DPARSF. Since there was confusion about which edition of DPARSF was applied, we incorrectly added a sentence about the regression process during our revision.

Na-Young Shin had performed the study in Yonsei University College of Medicine and her current affiliation is Ewha Womans University School of Medicine.

An erratum to this article is available at http://dx.doi.org/10.1007/s00330-017-4748-5.

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Kim, H.G., Shin, NY., Bak, Y. et al. Altered intrinsic brain activity after chemotherapy in patients with gastric cancer: A preliminary study. Eur Radiol 27, 2679–2688 (2017). https://doi.org/10.1007/s00330-016-4578-x

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