Altered intrinsic brain activity after chemotherapy in patients with gastric cancer: A preliminary study
- 339 Downloads
To characterize the pattern of altered intrinsic brain activity in gastric cancer patients after chemotherapy (CTx).
Patients before and after CTx (n = 14) and control subjects (n = 11) underwent resting-state functional MRI (rsfMRI) at baseline and 3 months after CTx. Regional homogeneity (ReHo), amplitude of low-frequency fluctuation (ALFF), and fractional ALFF (fALFF) were calculated and compared between the groups using the two-sample t test. Correlation analysis was also performed between rsfMRI values (i.e., ReHo, ALFF, and fALFF) and neuropsychological test results.
Patients showed poor performance in verbal memory and executive function and decreased rsfMRI values in the frontal areas even before CTx and showed decreased attention/working memory and executive function after CTx compared to the control subjects. In direct comparison of values before and after CTx, there were no significant differences in neuropsychological test scores, but decreased rsfMRI values were observed at the frontal lobes and right cerebellar region. Among rsfMRI values, lower ALFF in the left inferior frontal gyrus was significantly associated with poor performance of the executive function test.
We observed decreased attention/working memory and executive function that corresponded to the decline of frontal region activation in gastric cancer patients who underwent CTx.
• Intrinsic brain activity of gastric cancer patients after chemotherapy was described.
• Brain activity and neuropsychological test results were correlated.
• Working memory and executive function decreased after chemotherapy.
• Decreased cognitive function corresponded to decreased activation of the frontal region.
KeywordsGastric cancer Cancer chemotherapy agents Functional magnetic resonance imaging Brain Cognitive function
The scientific guarantor of this publication is Na-Young Shin. The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article. This work was supported by the Ewha Womans University Research Grant of 2015 (1-2015-0437-001-1). One of the authors has significant statistical expertise (Kyunghwa Han). Institutional review board approval was obtained. Written informed consent was obtained from all subjects (patients) in this study. Methodology: prospective, case-control study, performed at one institution.
- 20.Kendall MG, Gibbons JD (1990) Rank correlation methods, 5th edn. Oxford University Press, OxfordGoogle Scholar
- 21.Chao-Gan Y, Yu-Feng Z (2010) DPARSF: a MATLAB toolbox for “pipeline” data analysis of resting-state fMRI. Front Syst Neurosci 4Google Scholar
- 37.Diasio RB (2000) Oral DPD-inhibitory fluoropyrimidine drugs. Oncology (Williston Park) 14:19–23Google Scholar
- 50.Valentin LS, Pereira VF, Pietrobon RS, Schmidt AP, Oses JP, Portela LV et al (2016) Effects of single low dose of dexamethasone before noncardiac and nonneurologic surgery and general anesthesia on postoperative cognitive dysfunction-a phase III double blind, randomized clinical trial. PLoS One 11:e0152308CrossRefPubMedPubMedCentralGoogle Scholar