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Cardiac index after acute ST-segment elevation myocardial infarction measured with phase-contrast cardiac magnetic resonance imaging

  • Magnetic Resonance
  • Published:
European Radiology Aims and scope Submit manuscript



Phase-contrast CMR (PC-CMR) might provide a fast and robust non-invasive determination of left ventricular function in patients after ST-segment elevation myocardial infarction (STEMI).


Cine sequences in the left-ventricular (LV) short-axis and free-breathing, retrospectively gated PC-CMR were performed in 90 patients with first acute STEMI and 15 healthy volunteers. Inter- and intra-observer agreement was determined. The correlations of clinical variables (age, gender, ejection fraction, NT pro-brain natriuretic peptide [NT-proBNP] with cardiac index (CI) were calculated.


For CI, there was a strong agreement of cine CMR with PC-CMR in healthy volunteers (r: 0.82, mean difference: -0.14 l/min/m2, error ± 23 %). Agreement was lower in STEMI patients (r: 0.61, mean difference: -0.17 l/min/m2, error ± 32 %). In STEMI patients, CI measured with PC-CMR showed lower intra-observer (1 % vs. 9 %) and similar inter-observer variability (9 % vs. 12 %) compared to cine CMR. CI was significantly correlated with age, ejection fraction and NT-proBNP values in STEMI patients.


The agreement of PC-CMR and cine CMR for the determination of CI is lower in STEMI patients than in healthy volunteers. After acute STEMI, CI measured with PC-CMR decreases with age, LV ejection fraction and higher NT-proBNP.

Key Points

Cine CMR and PC-CMR correlate well in healthy volunteers.

Agreement is lower in STEMI patients.

Cardiac Output should be measured with one method longitudinally.

Cardiac output decreases with age after myocardial infarction.

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American College of Cardiology


Body mass index


Beat per minute


Body surface area


Cardiovascular magnetic resonance


Cardiac index


Cardiac Troponin T




Estimated glomerular filtration rate


European Society of Cardiology


Heart rate


Interquartile range


Late enhancement


Ejection fraction


N-terminal pro-B-type natriuretic peptide


New York Heart Association




Phase-sensitive inversion recovery


Primary percutaneous coronary intervention


Standard deviation


ST-segment elevation myocardial infarction


Stroke volume


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The scientific guarantor of this publication is Bernhard Metzler. The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article. This study has received funding by the Austria Society for Cardiology, Innsbruck Medical University and the Hans und Blanca Moser Stiftung.

One of the authors has significant statistical expertise. No complex statistical methods were necessary for this paper. Institutional Review Board approval was obtained. Written informed consent was obtained from all subjects (patients) in this study. Written informed consent was waived by the Institutional Review Board. Some study subjects or cohorts have been previously reported in MRI, IJC. All patients have been studied within the MARINA-STEMI registry at the Medical University of Innsbruck. Phase contrast data has not been previously published. Methodology: prospective, observational, performed at one institution.

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Correspondence to Gert Klug.

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Klug, G., Reinstadler, S.J., Feistritzer, HJ. et al. Cardiac index after acute ST-segment elevation myocardial infarction measured with phase-contrast cardiac magnetic resonance imaging. Eur Radiol 26, 1999–2008 (2016).

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