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European Radiology

, Volume 25, Issue 12, pp 3455–3458 | Cite as

Scaled signal intensity of uterine fibroids based on T2-weighted MR images: a potential objective method to determine the suitability for magnetic resonance-guided focused ultrasound surgery of uterine fibroids

  • Hyun Park
  • Sang-Wook YoonEmail author
  • Amit Sokolov
Interventional

Abstract

Objectives

Magnetic Resonance-guided Focused Ultrasound Surgery (MRgFUS) is a non-invasive method to treat uterine fibroids. To help determine the patient suitability for MRgFUS, we propose a new objective measure: the scaled signal intensity (SSI) of uterine fibroids in T2 weighted MR images (T2WI).

Methods

Forty three uterine fibroids in 40 premenopausal women were included in this retrospective study. SSI of each fibroid was measured from the screening T2WI by standardizing its mean signal intensity to a 0–100 scale, using reference intensities of rectus abdominis muscle (0) and subcutaneous fat (100). Correlation between the SSI and the non-perfused volume (NPV) ratio (a measure for treatment success) was calculated.

Results

Pre-treatment SSI showed a significant inverse-correlation with post treatment NPV ratio (p < 0.05). When dichotomizing NPV ratio at 45 %, the optimal cut off value of the SSI was found to be 16.0.

Conclusions

A fibroid with SSI value 16.0 or less can be expected to have optimal responses. The SSI of uterine fibroids in T2WI can be suggested as an objective parameter to help in patient selection for MRgFUS.

Key Points

• Signal intensity of fibroid in MR images predicts treatment response to MRgFUS.

• Signal intensity is standardized into scaled form using adjacent tissues as references.

• Fibroids with SSI less than 16.0 are expected to have optimal responses.

Keywords

Uterine fibroid Magnetic resonance imaging Scaled signal intensity Focused ultrasound Ablation 

Notes

Acknowledgements

The authors thank Cha Bok Chung and Eun Joo Baek for their help in managing the patients during MRgFUS treatment. We also thank Suk Hee Kim and Seon Ha Yun for their help in preparing the manuscript.

The scientific guarantor of this publication is Professor Sang-Wook Yoon. The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article. The authors state that this work has not received any funding. One of the authors has significant statistical expertise. Institutional Review Board approval was obtained.

Written informed consent was waived by the Institutional Review Board. Methodology: retrospective, observational study, performed at one institution.

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Copyright information

© European Society of Radiology 2015

Authors and Affiliations

  1. 1.Comprehensive Gynecologic Cancer Center, CHA Bundang Medical CenterCHA UniversityGyunggi-doRepublic of Korea
  2. 2.Department of Diagnostic Radiology, CHA Bundang Medical CenterCHA UniversitySungnam-siRepublic of Korea
  3. 3.InSightec Ltd.HaifaIsrael

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