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MRI to predict prostate growth and development in children, adolescents and young adults

  • Magnetic Resonance
  • Published:
European Radiology Aims and scope Submit manuscript

Abstract

Objectives

The purpose of this study was to investigate the use of MRI in predicting prostate growth and development.

Methods

A total of 1,500 healthy male volunteers who underwent MRI of the pelvis were included in this prospective study. Subjects were divided into five groups according to age (group A, 2–5 years; group B, 6–10 years; group C, 11-15 years; group D, 16-20 years; group E, 21-25 years). Total prostate volume (TPV) as well as prostate central zone (CZ) and peripheral zone (PZ) were measured and evaluated on MRI. Data of the different groups were compared using variance analysis, Scheffé's method, Kruskal–Wallis H-test, and Pearson’s correlation. Statistical significance was inferred at P < 0.05.

Results

In groups A and B, the prostates were barely visible. In group C, although TPV was measured, it was hard to distinguish CZ and PZ. In group D, 136 CZ and PZ were clearly visible. In group E, 377 CZ and PZ were clearly visible on T2-weighted imaging (T2WI). The median TPVs of groups A, B, C, D, and E were 0.00 cm3, 0.05 cm3, 2.83 cm3, 8.32 cm3, and 11.56 cm3, respectively, and the median prostate development scores were 0.08, 0.69, 1.56, 2.38, and 2.74, respectively. Both TPVs and zonal anatomy scores varied significantly among the five groups (P = 0.000). TPV and zonal anatomy score increased with increasing age.

Conclusions

MRI provides a reliable quantitative reference for prostate growth and development.

Key Points

• When and how the prostate develops after birth remains unclear.

• Prostate volume increases rapidly after the age of 10 years.

• MRI provides a reliable objective and quantitative reference for prostate growth and development.

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References

  1. Freddie B, Ahmedin J, Nathan G et al (2012) Global cancer transitions according to the Human Development Index (2008–2030): a population-based study. Lancet Oncol 13(8):790–801

    Article  Google Scholar 

  2. Siegel R, Naishadham D, Jemal A (2013) Cancer statistics, 2013. CA Cancer J Clin 63:11–30

    Article  PubMed  Google Scholar 

  3. Ren J, Yang Y, Zhang JS et al (2013) T2-weighted combined with diffusion-weighted images for evaluating prostatic transition zone tumors at 3 tesla. Future Oncol 9(4):585–93

    Article  CAS  PubMed  Google Scholar 

  4. Gossner J (2012) Computed tomography of the prostate – a review. Int J Radiol 14(1):1

    Google Scholar 

  5. Williams AM, Simon I, Landis PK et al (1999) Prostatic growth rate determined from MRI data: age-related longitudinal changes. J Androl 20(4):474–80

    CAS  PubMed  Google Scholar 

  6. Tamada T, Sone T, Toshimitsu S et al (2008) Age-related and zonal anatomical changes of apparent diffusion coefficient values in normal human prostatic tissues. J Magn Reson Imaging 27:552–6

    Article  PubMed  Google Scholar 

  7. Timms BG, Hofkamp LE (2011) Prostate development and growth in benign prostatic hyperplasia. Differentiation 82(45):173–83

    Article  CAS  PubMed  Google Scholar 

  8. Oesterling JE, Jacobsen SJ, Chute CG et al (1993) Serum prostate-specific antigen in a community-based population of healthy men: establishment of age-specific reference ranges. JAMA 270:860–4

    Article  CAS  PubMed  Google Scholar 

  9. Rhodes T, Girman CJ, Jacobsen SJ et al (1999) Longitudinal prostate growth rates during 5 years in randomly selected community men 40–79 years old. J Urol 161:1174–9

    Article  CAS  PubMed  Google Scholar 

  10. Jeong CW, Park HK, Hong SK et al (2008) Comparison of prostate volume measured by transrectal ultrasonography and MRI with the actual prostate volume measured after radical prostatectomy. Urol Int 81:179–85

    Article  PubMed  Google Scholar 

  11. Lee JS, Chung BH (2007) Transrectal ultrasound versus magnetic resonance imaging in the estimation of prostate volume as compared with radical prostatectomy specimens. Urol Int 78:323–7

    Article  PubMed  Google Scholar 

  12. Aarnink RG, de la Rosette JJ, Debruyne FM et al (1996) Formula-derived prostate volume determination. Eur Urol 29:399–402

    CAS  PubMed  Google Scholar 

  13. Bangma CH, Niemer AQ, Grobbee DE et al (1996) Transrectal ultrasonic volumetry of the prostate: in vivo comparison of different methods. Prostate 28:107–10

    Article  CAS  PubMed  Google Scholar 

  14. Eri LM, Thomassen H, Brennhovd B et al (2002) Accuracy and repeatability of prostate volume measurements by transrectal ultrasound. Prostate Cancer Prostatic Dis 5:273–8

    Article  CAS  PubMed  Google Scholar 

  15. Villeirs GM, Verstraete KL, De Neve WJ et al (2005) Magnetic resonance imaging anatomy of the prostate and periprostatic area: a guide for radiotherapists. Radiother Oncol 76:99–106

    Article  PubMed  Google Scholar 

  16. Shapiro E, Hartanto V, Perlman EJ et al (1997) Morphometric analysis of pediatric and nonhyperplastic prostate glands: evidence that BPH is not a unique stromal process. Prostate 33:177–82

    Article  CAS  PubMed  Google Scholar 

  17. Zondek T, Zondek LH (1975) The fetal and neonatal prostate. In: Goland M (ed) Normal and Abnormal Growth of the Prostate. Thomas, Springfield, pp 5–28

    Google Scholar 

  18. Aumuller G (1991) Postnatal development of the prostate. Bull Assoc Anat (Nancy) 75:39–42

    CAS  Google Scholar 

  19. Ingram S, Hollman AS, Azmy AF (1994) Ultrasound evaluation of the paediatric prostate. Br J Urol 74(5):601–3

    Article  CAS  PubMed  Google Scholar 

  20. Williams AM, Simon I, Landis PK et al (1999) Prostatic growth rate determined from MRI data: age-related longitudinal changes. J Androl 20:474–80

    CAS  PubMed  Google Scholar 

  21. Allen KS, Kressel HY, Arger PH et al (1989) Age-related changes of the prostate: evaluation by MR imaging. AJR 152:77–81

    Article  CAS  PubMed  Google Scholar 

  22. Turkbey B, Huang R, Vourganti S et al (2012) Age related changes in prostate zonal volume as measured by high resolution prostate MRI: a cross sectional study in over 500 patients. BJU Int 110(11):1642–7

    Article  PubMed  Google Scholar 

  23. Zaichick V, Zaichick S (2014) Age-related histological and zinc content changes in adult nonhyperplastic prostate glands. Age (Dordr) 36(1):167–81

    Article  CAS  Google Scholar 

  24. Zhang SJ, Qian HN, Zhao Y et al (2013) Relationship between age and prostate size. Asian J Androl 15:116–20

    Article  PubMed Central  PubMed  Google Scholar 

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Acknowledgments

The scientific guarantor of this publication is Professor Yi Huan. The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article. This study received funding from the National Natural Science of China Foundation and high-tech clinical projects of Xijing Hospital (Grants NSFC 81370039, NSFC 81220108011, and XJGX13LC11). No complex statistical methods were necessary for this paper. Institutional Review Board approval was obtained. Written informed consent was obtained from all subjects (patients) in this study. The study subjects or cohorts have not been previously reported. Methodology: retrospective diagnostic or prognostic study, performed at one institution.

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Authors and Affiliations

  1. Department of Radiology, Xijing Hospital, Fourth Military Medical University, Changle West Road #127, Xi’an City, People’s Republic of China, 710032

    Jing Ren, Huijia Liu, Didi Wen, Xufang Huang, Fang Ren & Yi Huan

  2. Department of Urology, Tangdu Hospital, Fourth Military Medical University, Xinsi Road 1#, Xi’an City, People’s Republic of China, 710038

    He Wang

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  1. Jing Ren
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  2. Huijia Liu
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  3. He Wang
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  4. Didi Wen
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  5. Xufang Huang
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  6. Fang Ren
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  7. Yi Huan
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Correspondence to Yi Huan.

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Ren, J., Liu, H., Wang, H. et al. MRI to predict prostate growth and development in children, adolescents and young adults. Eur Radiol 25, 516–522 (2015). https://doi.org/10.1007/s00330-014-3372-x

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  • DOI: https://doi.org/10.1007/s00330-014-3372-x

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