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Iterative reconstruction technique vs filter back projection: utility for quantitative bronchial assessment on low-dose thin-section MDCT in patients with/without chronic obstructive pulmonary disease

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Abstract

Objectives

The aim of this study was to evaluate the utility of the iterative reconstruction (IR) technique for quantitative bronchial assessment during low-dose computed tomography (CT) as a substitute for standard-dose CT in patients with/without chronic obstructive pulmonary disease.

Methods

Fifty patients (mean age, 69.2; mean % predicted FEV1, 79.4) underwent standard-dose CT (150mAs) and low-dose CT (25mAs). Except for tube current, the imaging parameters were identical for both protocols. Standard-dose CT was reconstructed using filtered back-projection (FBP), and low-dose CT was reconstructed using IR and FBP. For quantitative bronchial assessment, the wall area percentage (WA%) of the sub-segmental bronchi and the airway luminal volume percentage (LV%) from the main bronchus to the peripheral bronchi were acquired in each dataset. The correlation and agreement of WA% and LV% between standard-dose CT and both low-dose CTs were statistically evaluated.

Results

WA% and LV% between standard-dose CT and both low-dose CTs were significant correlated (r > 0.77, p < 0.00001); however, only the LV% agreement between SD-CT and low-dose CT reconstructed with IR was moderate (concordance correlation coefficient = 0.93); the other agreement was poor (concordance correlation coefficient <0.90).

Conclusions

Quantitative bronchial assessment via low-dose CT has potential as a substitute for standard-dose CT by using IR and airway luminal volumetry techniques.

Key points

• Quantitative bronchial assessment of COPD using low-dose CT is possible.

• Airway luminal volumetry with iterative reconstruction is insusceptible to dose reduction.

• Filtered back-projection is susceptible to the effect of dose reduction.

• Wall area percentage assessment is easily influenced by dose reduction.

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Abbreviations

COPD:

chronic obstructive pulmonary disease

FBP:

filtered back-projection

FEV1:

percent predicted forced expiratory volume in 1 s

IR:

iterative reconstruction

%LAA:

percentage of low attenuation area

LV%:

luminal volume percentage

PFT:

pulmonary function test

WA%:

wall area percentage

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Acknowledgments

The authors wish to thank Kazuyuki Kobayashi, M.D., Ph.D., Yasuhiro Funada, M.D., Ph.D., and Yoshikazu Kotani, M.D., Ph.D., Yoshihiro Nishimura, M.D., Ph.D., (Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine) and Yoshimasa Maniwa, M.D., Ph.D. (Department of General Thoracic Surgery, Kobe University Graduate School of Medicine).

This work was supported by grants-in-aid for scientific research from the Japanese Ministry of Education, Culture, Sports, Science and Technology (JSTS, KAKENHI; No. 22791197);　and Toshiba Medical Systems Corporation.

The scientific guarantor of this publication is Hisanobu Koyama, M.D., Ph.D., Kobe University School of Medicine. The authors of this manuscript declare relationships with the following companies: Toshiba Medical Systems Corporation. No complex statistical methods were necessary for this paper. Institutional Review Board approval was obtained. Written informed consent was obtained from all subjects (patients) in this study. Some study subjects have been previously reported by Nishio et al. [14]. However, the key points of our current study were different as our current study assessed the bronchus whereas the previous study assessed the lung parenchyma. New subjects were included in our current study. Methodology: retrospective, diagnostic or prognostic study, performed at one institution.

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Authors and Affiliations

  1. Division of Radiology, Department of Radiology, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan

    Hisanobu Koyama, Shinichiro Seki & Kazuro Sugimura

  2. Advanced Biomedical Imaging Research Centre, Kobe University Graduate School of Medicine, Kobe, Japan

    Yoshiharu Ohno, Mizuho Nishio, Sumiaki Matsumoto & Takeshi Yoshikawa

  3. Division of Functional and Diagnostic Imaging Research, Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Japan

    Yoshiharu Ohno, Mizuho Nishio, Sumiaki Matsumoto & Takeshi Yoshikawa

  4. Toshiba Medical Systems Corporation, Ohtawara, Tochigi, Japan

    Naoki Sugihara

Authors
  1. Hisanobu Koyama
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  2. Yoshiharu Ohno
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  3. Mizuho Nishio
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Correspondence to Hisanobu Koyama.

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Koyama, H., Ohno, Y., Nishio, M. et al. Iterative reconstruction technique vs filter back projection: utility for quantitative bronchial assessment on low-dose thin-section MDCT in patients with/without chronic obstructive pulmonary disease. Eur Radiol 24, 1860–1867 (2014). https://doi.org/10.1007/s00330-014-3207-9

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  • DOI: https://doi.org/10.1007/s00330-014-3207-9

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