Delayed gadolinium-enhanced MRI of the meniscus (dGEMRIM) in patients with knee osteoarthritis: relation with meniscal degeneration on conventional MRI, reproducibility, and correlation with dGEMRIC
To assess (1) whether normal and degenerated menisci exhibit different T1GD on delayed gadolinium-enhanced MRI of the meniscus (dGEMRIM), (2) the reproducibility of dGEMRIM and (3) the correlation between meniscus and cartilage T1GD in knee osteoarthritis (OA) patients.
In 17 OA patients who underwent dGEMRIM twice within 7 days, meniscus and cartilage T1GD was calculated. Meniscus pathology was evaluated on conventional MRI. T1GD in normal and degenerated menisci were compared using a Student’s t-test. Reproducibility was assessed using ICCs. Pearson’s correlation was calculated between meniscus and cartilage T1GD.
A trend towards lower T1GD in degenerated menisci (mean: 402 ms; 95 % CI: 359–444 ms) compared to normal menisci (mean: 448 ms; 95 % CI: 423–473 ms) was observed (p = 0.05). Meniscus T1GD ICCs were 0.85–0.90. The correlation between meniscus and cartilage T1GD was moderate in the lateral (r = 0.52–0.75) and strong in the medial compartment (r = 0.78–0.94).
Our results show that degenerated menisci have a clear trend towards lower T1GD compared to normal menisci. Since these results are highly reproducible, meniscus degeneration may be assessed within one delayed gadolinium-enhanced MRI simultaneously with cartilage. The strong correlation between meniscus and cartilage T1GD suggests concomitant degeneration in both tissues in OA, but also suggests that dGEMRIC may not be regarded entirely as sulphated glycosaminoglycan specific.
• dGEMRIM T1GDcan possibly be used to assess meniscal degeneration;
• dGEMRIM yields highly reproducible meniscal T1GDin early stage osteoarthritic patients;
• Concomitant degeneration of cartilage and meniscus tissue occurs in early stage osteoarthritis;
• dGEMRIC cannot be regarded as entirely sulphated glycosaminoglycan specific.
KeywordsOsteoarthritis, knee Menisci, tibial Magnetic resonance imaging Cartilage, articular dGEMRIC
Abbreviations and acronyms
- 95 % CI
95 % confidence interval
anterior horn of the meniscus
body mass index
delayed gadolinium-enhanced magnetic resonance imaging of cartilage
delayed gadolinium-enhanced magnetic resonance imaging of the meniscus
fast spin echo
intraclass correlation coefficient
magnetic resonance imaging
posterior horn of the meniscus
regions of interest
weight-bearing cartilage of the femoral condyles
weight-bearing cartilage of the tibial plateaus
- 9.Buckwalter JA, Mankin HJ (1998) Articular cartilage: degeneration and osteoarthritis, repair, regeneration, and transplantation. Instr Course Lect 47–1998:487–504Google Scholar
- 17.Mayerhoefer ME, Mamisch TC, Riegler G et al (2011) Gadolinium diethylenetriaminepentaacetate enhancement kinetics in the menisci of asymptomatic subjects: a first step towards a dedicated dGEMRIC (delayed gadolinium-enhanced MRI of cartilage)-like protocol for biochemical imaging of the menisci. NMR Biomed 24:1210–1215PubMedCrossRefGoogle Scholar
- 23.Studler U, White LM, Andreisek G, Luu S, Cheng HLM, Sussman MS (2010) Impact of motion on T1 mapping acquired with inversion recovery fast spin echo and rapid spoiled gradient recalled-echo pulse sequences for delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) in volunteers. J Magn Reson Imaging 32:394–398PubMedGoogle Scholar
- 39.Wiener E, Settles M, Weirich G, Schmidt C, Diederichs G (2011) The influence of collagen network integrity on the accumulation of gadolinium-based MR contrast agents in articular cartilage. 183:226–232. doi:10.1055/s-0029-1245739