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European Radiology

, Volume 23, Issue 12, pp 3271–3277 | Cite as

Multi-detector spiral CT study of the relationships between pulmonary ground-glass nodules and blood vessels

  • Feng Gao
  • Ming Li
  • Xiaojun Ge
  • Xiangpeng ZhengEmail author
  • Qingguo Ren
  • Yan Chen
  • Fangzhen Lv
  • Yanqing HuaEmail author
Chest

Abstract

Objective

To investigate the relationships between pulmonary ground-glass nodules (GGN) and blood vessels and their diagnostic values in differentiating GGNs.

Methods

Multi-detector spiral CT imaging of 108 GGNs was retrospectively reviewed. The spatial relationships between GGNs and supplying blood vessels were categorized into four types: I, vessels passing by GGNs; II, intact vessels passing through GGNs; III, distorted, dilated or tortuous vessels seen within GGNs; IV, more complicated vasculature other than described above. Relationship types were correlated to pathologic and/or clinical findings of GGNs.

Results

Of 108 GGNs, 10 were benign, 24 preinvasive nodules and 74 adenocarcinomas that were pathologically proven. Types I, II, III and IV vascular relationships were observed in 9, 58, 21 and 20 GGNs, respectively. Type II relationship was the dominating relationship for each GGN group, but significant differences were shown among them. Correlation analysis showed strong correlation between invasive adenocarcinoma and type III and IV relationships. Subgroup analysis indicated that type III was more commonly seen in IAC with comparison to type IV more likely seen in MIA.

Conclusion

Different GGNs have different relationships with vessels. Understanding and recognising characteristic GGN-vessel relationships may help identify which GGNs are more likely to be malignant.

Key Points

Multi-detector CT offers new information about ground-glass nodules

In particular we can now study their relationship with vessels

Different types of ground-glass nodules have different relationships with vessels

This may help identify which ground-glass nodules are likely to be malignant

Keywords

Vessel Ground-glass nodule Tomography Adenocarcinoma X-ray computed 

Notes

Acknowledgement

Feng Gao and Ming Li contributed equally to this article.

This study was partly financially supported by the Science and Technology Commission Foundation of Shanghai (no. 10411952600, 124119a0400) and the Young Investigator Fund of Fudan University (grant no. EYF163006).

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Copyright information

© European Society of Radiology 2013

Authors and Affiliations

  • Feng Gao
    • 1
  • Ming Li
    • 1
  • Xiaojun Ge
    • 1
  • Xiangpeng Zheng
    • 2
    Email author
  • Qingguo Ren
    • 1
  • Yan Chen
    • 3
  • Fangzhen Lv
    • 4
  • Yanqing Hua
    • 1
    Email author
  1. 1.Department of RadiologyHuadong Hospital Fudan UniversityShanghaiChina
  2. 2.Department of Radiation OncologyHuadong Hospital Fudan UniversityShanghaiChina
  3. 3.Department of PathologyHuadong Hospital Fudan UniversityShanghaiChina
  4. 4.Department of Thoracic SurgeryHuadong Hospital Fudan UniversityShanghaiChina

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