Skip to main content

Advertisement

SpringerLink
Log in

Percutaneous radiofrequency ablation of small renal tumours in patients with a single functioning kidney: long-term results

  • Interventional
  • Published:
European Radiology Aims and scope Submit manuscript

Abstract

Objectives

To evaluate the long-term results of percutaneous radiofrequency ablation (RFA) of small renal tumours in patients with a single functioning kidney (SFK).

Methods

This is a single-centre prospective study. Patients with an SFK and a tumour smaller than 3.5 cm, treated with RFA over a 7.5-year period, were included. Nineteen consecutive patients (12 male), aged between 33 and 83 years (mean 61.4), were treated for 23 lesions. Primary endpoints were technical success and tumour recurrence rate. Secondary endpoints were the deterioration of renal function and overall survival rate.

Results

The mean follow-up was 56.1 months (range 36–102). Primary technical success was 100 %. There were no major peri-procedural complications. In two cases, minor complications occurred. There was no significant difference between the baseline glomerular filtration rate (GFR) and GFR at 3, 12 and 24 months post-procedure. In four lesions (17 %), recurrence was detected and an additional RFA session was performed. None of the patients developed renal failure during their lifetime. Three of the patients died because of other reasons.

Conclusions

Percutaneous RFA of small renal tumours in patients with an SFK offers very satisfactory long-term results regarding preservation of renal function, local tumour control and overall survival.

Key Points

• Tumour in a single functioning kidney requires minimally invasive treatment.

• Radiofrequency ablation plays an established role in managing small renal tumours.

• Long-term results of radiofrequency ablation have shown satisfactory local tumour control.

• Long-term results have also shown that renal function may be preserved.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Wallen EM, Pruthi RS, Joyce GF, Wise M (2007) Kidney cancer. J Urol 177:2006–2018

    Article  PubMed  Google Scholar 

  2. Hoffmann RT, Jakobs TF, Kubisch CH et al (2007) Renal cell carcinoma in patients with a solitary kidney after nephrectomy treated with radiofrequency ablation: mid term results. Eur J Radiol 73:652–656

    Article  Google Scholar 

  3. Uzzo RG, Novick AC (2001) Nephron sparing surgery for renal tumors: indications, techniques and outcomes. J Urol 166:6–18

    Article  PubMed  CAS  Google Scholar 

  4. Miller DC, Schonlau M, Litwin MS, Lai J, Saigal CS, Urologic Diseases in America Project (2008) Renal and cardiovascular morbidity after partial or radical nephrectomy. Cancer 112:511–520

    Article  PubMed  Google Scholar 

  5. Sabharwal R, Vladica P (2006) Renal tumors: technical success and early clinical experience with radiofrequency ablation of 18 tumors. Cardiovasc Interv Radiol 29:202–209

    Article  Google Scholar 

  6. Gervais DA, Arellano RS, Mueller PR (2005) Percutaneous radiofrequency ablation of renal cell carcinoma. Radiology 15:960–967

    Google Scholar 

  7. Zlotta AR, Wildschutz T, Raviv G et al (1997) Radiofrequency interstitial tumor ablation (RITA) is a possible new modality for treatment of renal cancer: ex vivo and in vivo experience. J Endourol 11:251–2581

    Article  PubMed  CAS  Google Scholar 

  8. Farrell MA, Charboneau WJ, DiMarco DS et al (2003) Imaging-guided radiofrequency ablation of solid renal tumors. AJR Am J Roentgenol 180:1509–1513

    Article  PubMed  CAS  Google Scholar 

  9. Mylona S, Kokkinaki A, Pomoni M, Galani P, Ntai S, Thanos L (2008) Percutaneous radiofrequency ablation of renal cell carcinomas in patients with solitary kidney: 6 years experience. Eur J Radiol 69:351–356

    Article  PubMed  Google Scholar 

  10. Silverman SG, Lee BY, Seltzer SE, Bloom DA, Corless CL, Adams DF (1994) Small (<3 cm) renal masses: correlation of spiral CT features and pathologic findings. AJR Am J Roentgenol 163:597–605

    Article  PubMed  CAS  Google Scholar 

  11. Therasse P, Arbuck SG, Eisenhauer EA et al (2000) New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J Natl Cancer Inst 92:205–216

    Article  PubMed  CAS  Google Scholar 

  12. Goldberg SN, Grassi CJ, Cardella JF et al (2009) Image-guided tumor ablation: standardization of terminology and reporting criteria. J Vasc Interv Radiol 20:S377–S390

    Article  PubMed  Google Scholar 

  13. Malloy PC, Grassi CJ, Kundu S et al (2009) Consensus guidelines for periprocedural management of coagulation status and hemostasis risk in percutaneous image-guided interventions. J Vasc Interv Radiol 20:S240–S249

    Article  PubMed  Google Scholar 

  14. Clark TW, Millward SF, Gervais DA et al (2006) Reporting standards for percutaneous thermal ablation of renal cell carcinoma. J Vasc Interv Radiol 17:1563–1570

    Article  PubMed  Google Scholar 

  15. Jacobsohn K, Ahrar K, Wood C, Matin SF (2007) Is radiofrequency ablation safe for solitary kidneys? Urology 69:819–823

    Article  PubMed  Google Scholar 

  16. Syvanthong C, Wile G, Zagoria R (2007) Effect of radiofrequency ablation of renal tumours on renal function in patients with a solitary kidney. AJR Am J Roentgenol 188:1619–1621

    Article  PubMed  Google Scholar 

  17. Prevoo W, van den Munckhof MP, Meinhardt W, Horenblas S, van den Bosch MA (2010) Radiofrequency ablation of kidney tumours in patients with a solitary kidney. Clin Radiol 65:230–236

    Article  PubMed  CAS  Google Scholar 

  18. Raman JD, Raj GV, Lucas SM et al (2010) Renal functional outcomes for tumours in a solitary kidney managed by ablative or extirpative techniques. BJU Int 105:496–500

    Article  PubMed  Google Scholar 

  19. Park BK, Kim CK (2009) Complications of image-guided radiofrequency ablation of renal cell carcinoma: causes, imaging features and prevention methods. Eur Radiol 19:2180–2190

    Article  PubMed  Google Scholar 

  20. Fotiadis NI, Sabharwal T, Morales JP, Hodgson DJ, O’Brien TS, Adam A (2007) Combined percutaneous radiofrequency ablation and ethanol injection of renal tumours: midterm results. Eur Urol 52:777–784

    Article  PubMed  Google Scholar 

  21. Shankar S, vanSonneberg E, Morrison PR, Tuncali K, Silverman SG (2004) Combined radiofrequency and alcohol injection for percutaneous hepatic tumor ablation. AJR Am J Roentgenol 183:1425–1429

    Article  PubMed  Google Scholar 

  22. Lee JM, Lee YH, Kim YK, Kim SW, Kim CS (2004) Combined therapy of radiofrequency ablation and ethanol injection of rabbit liver: an in vivo feasibility study. Cardiovasc Interv Radiol 27:151–157

    Google Scholar 

  23. Malcolm JB, Logan JE, Given RW et al (2010) Renal functional outcomes after cryoablation of small renal masses. J Endourol 24:479–482

    Article  PubMed  Google Scholar 

  24. Weisbrod AJ, Atwell TD, Frank I et al (2010) Percutaneous cryoablation of masses in a solitary kidney. AJR Am J Roentgenol 194:1620–1625

    Article  PubMed  Google Scholar 

  25. Altunrende F, Autorino R, Hillyer S et al (2011) Image guided percutaneous probe ablation for renal tumors in 65 solitary kidneys: functional and oncological outcomes. J Urol 186:35–41

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

Some of the patients included in this study were also included in previously published midterm results of RFA in our centre: Fotiadis N, Sabharwal T, Morales P, Hodgson D, O’Brien T, Adam A (2007) Combined percutaneous radiofrequency ablation and ethanol injection of renal tumours: midterm results. Eur Urol 52:777–84

One case was also published as a case report when performed because of the combined MRI and fluoroscopy access: Fotiadis NI, Sabharwal T, Gangi A, Adam A (2009) Combined MRI and fluoroscopic guided radiofrequency ablation of a renal tumor. Cardiovasc Intervent Radiol 32:184–7

Author information

Authors and Affiliations

  1. Department of Radiology, Guy’s and St Thomas’ Hospitals NHS Foundation Trust, 1st Floor Lambeth Wing, Westminster Bridge Road, SE1 7EH, London, UK

    Miltiadis Krokidis, Stavros Spiliopoulos, Magdalena Jarzabek, Tarun Sabharwal & Andy Adam

  2. Department of Radiology, The Royal Marsden NHS Foundation Trust, London, UK

    Nikos Fotiadis

  3. Department of Urology, Guy’s and St Thomas’ Hospitals NHS Foundation Trust, London, UK

    Tim O’Brien

Authors
  1. Miltiadis Krokidis
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Stavros Spiliopoulos
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Magdalena Jarzabek
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Nikos Fotiadis
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Tarun Sabharwal
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Tim O’Brien
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Andy Adam
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Miltiadis Krokidis.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Krokidis, M., Spiliopoulos, S., Jarzabek, M. et al. Percutaneous radiofrequency ablation of small renal tumours in patients with a single functioning kidney: long-term results. Eur Radiol 23, 1933–1939 (2013). https://doi.org/10.1007/s00330-013-2802-5

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00330-013-2802-5

Keywords

Search

Navigation