Prospective evaluation of magnetic resonance enterography for the detection of mesenteric small bowel tumours
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To prospectively evaluate magnetic resonance (MR) enterography for detecting mesenteric small-bowel tumours (MSBTs) and assess the added value of gadolinium-chelate injection.
Material and methods
Over a 2-year period MR enterography examinations of 75 patients (33 men, 42 women; mean age, 53.8 years; range, 19–85) with suspected MSBT were blindly analysed by two readers for the presence of MSBT. Sensitivities, specificities, predictive positive values (PPVs), negative predictive values (NPVs) and accuracies of MR enterography for the detection of MSBT were calculated on per-patient and per-lesion bases. The McNemar test was used to compare sensitivities and specificities of the unenhanced and gadolinium-enhanced sets of MR enterographies.
Thirty-seven MSBTs were pathologically confirmed in 26 patients. The mean tolerance score of the examinations was 0.7. On a per-patient basis, sensitivity, specificity, PPV, NPV and accuracy for detection of MSBT were 96 % [95 % CI, 89–100 %], 96 % [90–100 %], 93 % [83–100 %], 98 % [94–100 %] and 96 % [92–100 %], respectively. On a per-lesion basis, sensitivity and PPV were 70 % [56–85 %] and 93 % [83–100 %], respectively. Gadolinium injection yielded higher sensitivities on both bases (P = 0.008).
MR enterography is an accurate and well-tolerated imaging modality for detecting MSBT. Intravenous administration of gadolinium-chelate improves sensitivity for MSBT detection.
• MR enterography accurately detects mesenteric small bowel tumours.
• MR enterography is a well-tolerated imaging technique.
• Intravenous administration of gadolinium chelate improves sensitivity for detecting small-bowel tumours.
KeywordsMR imaging MR enterography Small-bowel tumours Tumour Gadolinium
Mesenteric small-bowel tumour
Half-Fourier single-shot spin echo
True free-induction with steady state free precession
Volumetric interpolated breath-hold
Gastrointestinal stromal tumour
The authors did not receive any support for this article.
G. Cadiot is a board member of Mayoli Spindler and is a consultant for Novartis and Kéocyt; he has received payments for lectures, including service on speakers bureaus, from Ipsen, Novartis, Biocodex, Abbott and Mayoli Spindler, for manuscript preparation from Novartis and for the development of educational presentations from Pfizer and Ipsen; he has also received travel, accommodation and meeting expenses from Ferring.
- 7.Soyer P, Aout M, Hoeffel C, Vicaut E, Placé V, Boudiaf M (2013) Helical CT-enteroclysis in the detection of small-bowel tumours: a meta-analysis. Eur Radiol 23:388-399Google Scholar
- 16.Caspari R, Von Falkenhausen M, Krautmacher C, Schild H, Heller J, Sauerbruch T (2004) Comparison of capsule endoscopy and magnetic resonance imaging for the detection of polyps of the small intestine in patients with familial adenomatous polyposis or with Peutz-Jeghers syndrome. Endoscopy 36:1054–1059PubMedCrossRefGoogle Scholar
- 22.Pappalardo G, Gualdi G, Nunziale A, Masselli G, Floriani I, Casciani E (2012) The impact of magnetic resonance in the preoperative staging and the surgical planning for treating small bowel neoplasms. Surg Today. doi: 10.1007/s00595-012-0270-1