European Radiology

, Volume 23, Issue 5, pp 1297–1298 | Cite as

Letter to the Editor re: Perfusion MRI for the prediction of treatment response after preoperative chemoradiotherapy in locally advanced rectal cancer

  • Marc J. GollubEmail author
  • D. H. Gultekin
  • L. H. Schwartz

Key Points

Rectal cancer treatment can be monitored by perfusion MRI.

Ktrans values vary between responders and non-responders.

Radiation and chemotherapy may affect Ktrans differently.

Dear Editor,

We congratulate Lim et al. [ 1] on their study investigating DCE-MRI and rectal cancer. In this well-performed and important study, the authors found that pretreatment K trans was able to distinguish between responders and non-responders to neoadjuvant chemoradiation in locally advanced, circumferential margin-threatened T3 tumours. Having performed a similar study, published in the same journal, Gollub et al. [ 2] did not find that pretreatment K trans had predictive value, but rather that post-treatment K transin a select group of patients undergoing neoadjuvant chemotherapy only was able to distinguish pathological complete responders from incomplete responders. As the authors of that article, we would like to make several comments, while at the same time emphasise, along with Lim et...


Rectal Cancer Bevacizumab Advanced Rectal Cancer Important Clinical Question Rectal Cancer Treatment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Lim JS, Kim D, Baek SE et al (2012) Perfusion MRI for the prediction of treatment response after preoperative chemoradiotherapy in locally advanced rectal cancer. Eur Radiol 22:1693–1700PubMedCrossRefGoogle Scholar
  2. 2.
    Gollub MJ, Gultekin DH, Akin O et al (2012) Dynamic contrast enhanced-MRI for the detection of pathological complete response to neoadjuvant chemotherapy for locally advanced rectal cancer. Eur Radiol 22:821–831PubMedCrossRefGoogle Scholar
  3. 3.
    Habr-Gama A, Perez RO, Proscurshim I et al (2006) Patterns of failure and survival for nonoperative treatment of stage c0 distal rectal cancer following neoadjuvant chemoradiation therapy. J Gastrointest Surg 10:1319–1328, discussion 1328–1329PubMedCrossRefGoogle Scholar
  4. 4.
    Lambregts DM, Beets GL, Maas M et al (2011) Tumour ADC measurements in rectal cancer: effect of ROI methods on ADC values and interobserver variability. Eur Radiol 21:2567–2574PubMedCrossRefGoogle Scholar

Copyright information

© European Society of Radiology 2012

Authors and Affiliations

  • Marc J. Gollub
    • 1
    • 4
    Email author
  • D. H. Gultekin
    • 2
  • L. H. Schwartz
    • 3
  1. 1.Department of RadiologyMemorial Sloan-Kettering Cancer CenterNew YorkUSA
  2. 2.Department of Medical PhysicsMemorial Sloan-Kettering Cancer CenterNew YorkUSA
  3. 3.Department of RadiologyColumbia University Medical Center/New York Presbyterian HospitalNew YorkUSA
  4. 4.Memorial Sloan-Kettering Cancer Center - RadiologyNew YorkUSA

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