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Malignant versus benign mediastinal lesions: quantitative assessment with diffusion weighted MR imaging

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Abstract

Objectives

We aimed to evaluate the performance of diffusion-weighted magnetic resonance imaging in differentiating malignant from benign mediastinal lesions.

Methods

Fifty-three mediastinal lesions were examined with T1- and T2-weighted (W) conventional images. Then, two diffusion-weighted images were obtained with b = 0 and 1000 s/mm² values and apparent diffusion coefficients (ADC) were calculated. The statistical significance of differences between measurements was tested using the Student-t test.

Results

The mean ADC of malignant lesions was significantly lower than that of the benign masses (p < 0.001). The cut-off value of ≤ 1.39 × 10−3 mm²/s indicated a malignant lesion with a sensitivity of 95% and specificity of 87%.

Conclusion

Diffusion-weighted imaging may be helpful in differentiating benign from malignant mediastinal masses.

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Authors and Affiliations

  1. Department of Radiology, School of Medicine, University of Kocaeli, Kocaeli Uni. Tip Fak Radyoloji AD, 41380, Umuttepe Kocaeli, Turkey

    Sevtap Gümüştaş, Nagihan İnan, Hasan Tahsin Sarisoy, Yonca Anik, Arzu Arslan, Ercüment Çiftçi, Gür Akansel & Ali Demirci

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  1. Sevtap Gümüştaş
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  2. Nagihan İnan
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  3. Hasan Tahsin Sarisoy
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  4. Yonca Anik
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  5. Arzu Arslan
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  6. Ercüment Çiftçi
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  7. Gür Akansel
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  8. Ali Demirci
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Correspondence to Sevtap Gümüştaş.

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Gümüştaş, S., İnan, N., Sarisoy, H.T. et al. Malignant versus benign mediastinal lesions: quantitative assessment with diffusion weighted MR imaging. Eur Radiol 21, 2255–2260 (2011). https://doi.org/10.1007/s00330-011-2180-9

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  • DOI: https://doi.org/10.1007/s00330-011-2180-9

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