Abstract
Objectives
To determine whether Radiofrequency Ablation (RFA) followed by Radiotherapy (RT) (RFA-RT) produces better palliation in terms of pain than RT alone in patients with osteolytic bone metastases.
Methods
Patients with solitary bone metastases and a pain score of least 5 or more on the VAS scale were selected. Fifteen patients were treated with RFA-RT (20 Gy delivered in 5 fractions of 4 Gy over 1 week) and were compared with a matched group (30 subjects) treated by RT.
Results
A complete response in terms of pain relief at 12 weeks was documented in 16.6% (5/30) and 53.3% (8/15) of the subjects treated by RT or RFA-RT, respectively (p = 0.027). The overall response rate at 12 weeks was 93.3% (14 patients) in the group treated by RFA-RT and 59.9% (18 patients) in the group treated by RT (p = 0.048). Although recurrent pain was documented more frequently after RT (26.6%) than after RFA-RT (6.7%) the difference did not reach statistical significance. The morbidity related to RT did not significantly differ when this treatment was associated with RFA.
Conclusions
Our results suggest that RFA-RT is safe and more effective than RT. The findings described here should serve as a framework around which to design future clinical trials.
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References
Chow E, Harris K, Fan G et al (2007) Palliative radiotherapy trials for bone metastases: a systematic review. J Clin Oncol 25:1423–1436
Janjan N, Lutz ST, Bedwinek JM et al (2009) Therapeutic guidelines for the treatment of bone metastasis: a report from the American College of Radiology Appropriateness Criteria Expert Panel on Radiation Oncology. J Palliat Med 12:417–426
Lo SS, Sahagal A, Hartsell WF et al (2009) The treatment of bone metastasis with highly conformal radiation therapy: a brave new world or a costly mistake. Clin Oncol 21:662–664
Callstrom MR, Charboneau JW, Goetz MP et al (2002) Painful metastases involving bone: feasibility of percutaneous CT and US guided radiofrequency ablation. Radiology 224:87–97
Goetz MP, Callstrom MR, Charboneau JW (2004) Percutaneous image-guided radiofrequency ablation of painful metastasis involving bone: a multicenter study. J Clin Oncol 22:300–306
Dupuy DE, Liu D, Hartfeil D et al (2010) Percutaneous radiofrequency ablation of painful osseous metastases: a multicenter American College of Radiology Imaging Network trial. Cancer 116:989–997
Widmann G, Bodner G, Bale R (2009) Tumour ablation: technical aspects. Cancer Imaging 9:63–67
Di Staso M, Zugaro L, Gravina GL, Bonfili P, Marampon F, Di Nicola L, Conchiglia A, Franzese P, Gallucci M, Masciocchi C, Tombolini V (2011) Can Radiotherapy be Combined with Radiofrequency Ablation in the Management of Symptomatic Osteolytic Skeletal Metastasis? Clin Oncol 23:65–66
Harris W, Li K, Flynn C et al (2007) Worst, average or current pain in the Brief Pain Inventory: which should be used to calculate the response to palliative radiotherapy in patients with bone metastases. Clin Oncol 19:523–527
Chow E, Wu JS, Hoskin P et al (2002) International consensus on palliative radiotherapy endpoints for future clinical trials in bone metastases. Radiother Oncol 64:275–280
Goldberg SN, Grassi CJ, Cardella JF et al (2005) Society of interventional radiology technology assessment committee; international working group on image-guided tumor ablation. Imaged-guided tumor ablation: standardization of terminology and reporting criteria. Radiology 235:728–739
Lutz S, Hoskin P, Chow E (2009) Update on palliative radiotherapy endpoints for bone metastases trials. Clin Oncol 21:659–661
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M. Di Staso, L. Zugaro and G. L. Gravina have Equal Contribution
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Di Staso, M., Zugaro, L., Gravina, G.L. et al. A feasibility study of percutaneous radiofrequency ablation followed by radiotherapy in the management of painful osteolytic bone metastases. Eur Radiol 21, 2004–2010 (2011). https://doi.org/10.1007/s00330-011-2133-3
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DOI: https://doi.org/10.1007/s00330-011-2133-3