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Comparison of semi-automated and manual methods to measure the volume of liver tumours on MDCT images

European Radiology volume 21, pages 996–1003 (2011)Cite this article

Abstract

Objective

To retrospectively compare semi-automated and manual volume measurements of malignant liver tumours and inter- and intra-observer variability using commercially available software.

Methods

This study was performed on 60 consecutive patients with untreated liver metastases (30) and HCCs (30), i.e. 92 lesions (49 metastases, 43 HCCs) using hepatic MDCT. Lesion volumes were manually measured independently by two radiologists and semi-automatically by the same two radiologists and a technician. Those measurements were repeated on 20 patients (10 metastases and 10 HCCs) a week later. An independent operator timed all the measurements. Using the Spearman correlation coefficient and Bland-Altman plots, statistical analyses were performed.

Results

Liver lesion volumes obtained with semi-automated and manual methods were well correlated (Spearman, r = 0.98 and 0.91). Their agreement was high for intra-observer measurements with the semi-automated method (Spearman, r = 0.91 and 0.94). The agreement was lower for inter-observer measurements with both methods (Spearman, r = 0.87 for semi-automated and 0.91 for manual). The semi-automated method significantly reduced the post-processing duration (23s ± 19s vs. 33s ± 11s, p value <0.0001).

Conclusion

In our study, semi-automated volume analysis of malignant liver tumours correlated well with the manual method. Furthermore, the semi-automated volume analysis was significantly quicker.

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Authors and Affiliations

  1. Assistance Publique des Hôpitaux de Paris, APHP, Department of Radiology, Hôpital Beaujon, 100 bd du Général Leclerc, 92110, Clichy, France

    Léna Dubus, Mathilde Gayet, Magaly Zappa, Liliane Abaleo, Aurélie De Cooman & Valérie Vilgrain

  2. GE HealthCare, Buc, France

    Guillaume Orieux

  3. Université Paris7 Denis Diderot, 75018, Paris, France

    Valérie Vilgrain

  4. INSERM Centre de recherche Biomédicale Bichat Beaujon, CRB3 U773, 75018, Paris, France

    Valérie Vilgrain

Authors
  1. Léna Dubus
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  2. Mathilde Gayet
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  3. Magaly Zappa
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  4. Liliane Abaleo
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  5. Aurélie De Cooman
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  6. Guillaume Orieux
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  7. Valérie Vilgrain
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Correspondence to Valérie Vilgrain.

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Dubus, L., Gayet, M., Zappa, M. et al. Comparison of semi-automated and manual methods to measure the volume of liver tumours on MDCT images. Eur Radiol 21, 996–1003 (2011). https://doi.org/10.1007/s00330-010-2013-2

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  • DOI: https://doi.org/10.1007/s00330-010-2013-2

Keywords

  • Liver neoplasms
  • CT
  • Tumor
  • Volumetry
  • Liver tumor
  • Tumor response
  • Semi-automated volumetry