Exposure to low-dose radiation and the risk of breast cancer among women with a familial or genetic predisposition: a meta-analysis
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Women with familial or genetic aggregation of breast cancer are offered screening outside the population screening programme. However, the possible benefit of mammography screening could be reduced due to the risk of radiation-induced tumours. A systematic search was conducted addressing the question of how low-dose radiation exposure affects breast cancer risk among high-risk women.
A systematic search was conducted for articles addressing breast cancer, mammography screening, radiation and high-risk women. Effects of low-dose radiation on breast cancer risk were presented in terms of pooled odds ratios (OR).
Of 127 articles found, 7 were selected for the meta-analysis. Pooled OR revealed an increased risk of breast cancer among high-risk women due to low-dose radiation exposure (OR = 1.3, 95% CI: 0.9– 1.8). Exposure before age 20 (OR = 2.0, 95% CI: 1.3–3.1) or a mean of ≥5 exposures (OR = 1.8, 95% CI: 1.1–3.0) was significantly associated with a higher radiation-induced breast cancer risk.
Low-dose radiation increases breast cancer risk among high-risk women. When using low-dose radiation among high-risk women, a careful approach is needed, by means of reducing repeated exposure, avoidance of exposure at a younger age and using non-ionising screening techniques.
KeywordsBreast cancer BRCA1/2 Family history Low-dose radiation Radiation effects Screening
We thank Mr. David Goldgar on behalf of the IBCCS study for providing additional information for the subgroup analysis.
- 1.Dutch Cancer Registry (2006) Available via IKCnet. http://www.ikcnet.nl. Accessed 28 April 2010
- 14.Shapiro S, Coleman EA, Broeders M et al (1998) Breast cancer screening programmes in 22 countries: current policies, administration and guidelines. international breast cancer screening network (IBSN) and the European network of pilot projects for breast cancer screening. Int J Epidemiol 27:735–742CrossRefPubMedGoogle Scholar
- 18.Lee CH, Dershaw DD, Kopans D et al (2010) Breast cancer screening with imaging: recommendations from the Society of breast imaging and the ACR on the use of mammography, breast MRI, breast ultrasound, and other technologies for the detection of clinically occult breast cancer. J Am Coll Radiol 7:18–27CrossRefPubMedGoogle Scholar
- 31.Den Otter W, Merchant TE, Beijerink D et al (1993) Exclusion from mammographic screening of women genetically predisposed to breast cancer will probably eliminate mammographically induced breast cancer. Anticancer Res 13:1113–1116Google Scholar
- 32.Den Otter W, Merchant TE, Beijerink D et al (1996) Breast cancer induction due to mammographic screening in hereditarily affected women. Anticancer Res 16:3173–3176Google Scholar
- 36.Andrieu N, Easton DF, Chang-Claude J et al (2006) Effect of chest X-rays on the risk of breast cancer among BRCA1/2 mutation carriers in the international BRCA1/2 carrier cohort study: a report from the EMBRACE, GENEPSO, GEO-HEBON, and IBCCS Collaborators' Group. J Clin Oncol 24:3361–3366CrossRefPubMedGoogle Scholar
- 40.Ma H, Hill CK, Bernstein L, Ursin G (2008) Low-dose medical radiation exposure and breast cancer risk in women under age 50 years overall and by estrogen and progesterone receptor status: results from a case-control and case-case comparison. Breast Cancer Res Treat 109:77–90CrossRefPubMedGoogle Scholar
- 43.Wells GA, Shea B, O'Connell J et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. http://www.ohri.ca/programs/clinical_epidemiology/oxford.htm
- 45.Vandenbroucke JP, Hofman A (1999) Principles of epidemiology. Reed Business, AmsterdamGoogle Scholar