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Laser-induced thermotherapy (LITT)—evaluation of a miniaturised applicator and implementation in a 1.0-T high-field open MRI applying a porcine liver model

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Abstract

Objective:

To evaluate the feasibility and safety of a novel LITT applicator for thermal ablation of liver malignancies in 1.0-T high-field open MRI.

Methods:

A miniaturised 6-F double-tubed protective catheter with a closed cooling circuit was used with a flexible laser fibre, connected to a 1,064-nm Nd:YAG laser and evaluated in non-perfused porcine livers (18–30 W for 10–20 min, 2-W and 2-min increments; n = 210/applicator) in reference to an established 9-F system. As a proof of concept, MR-guided LITT was performed in two healthy domestic pigs in high-field open MRI.

Results:

Ex-vivo, the coagulation volumes induced by the 6-F system with maximum applicable power of 24 W for 20 min (33.0 ± 4.4 cm3) did not differ significantly from those set with the 9-F system at 30 W for 20 min (35.8 ± 4.9 cm3) (p = 0.73). A flow-rate of 15 ml/min of the cooling saline solution was sufficient. MR navigation and thermometry were feasible.

Conclusion:

The miniaturised 6-F applicator can create comparable coagulation sizes to those of the 9-F system. Applicator guidance and online-thermometry in high-field open MRI are feasible.

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Authors and Affiliations

  1. Department of Radiology, Charité, Humboldt-Universität zu Berlin, Charitéplatz 1, 10117, Berlin, Germany

    Florian Streitparth, Gesine Knobloch, J. Rump, Uta Wonneberger, Bernd Hamm & Ulf Teichgräber

  2. Somatex Medical Technologies GmbH, Teltow, Germany

    Dirk Balmert

  3. Department of General, Visceral, and Transplantation Surgery, Charité, Humboldt-University, Berlin, Germany

    Sascha Chopra

  4. Department of Laser Medicine, Elisabeth Klinik, Berlin, Germany

    Carsten Philipp

Authors
  1. Florian Streitparth
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  2. Gesine Knobloch
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  3. Dirk Balmert
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  4. Sascha Chopra
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  5. J. Rump
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  6. Uta Wonneberger
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  7. Carsten Philipp
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  8. Bernd Hamm
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  9. Ulf Teichgräber
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Corresponding author

Correspondence to Florian Streitparth.

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Streitparth, F., Knobloch, G., Balmert, D. et al. Laser-induced thermotherapy (LITT)—evaluation of a miniaturised applicator and implementation in a 1.0-T high-field open MRI applying a porcine liver model. Eur Radiol 20, 2671–2678 (2010). https://doi.org/10.1007/s00330-010-1831-6

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  • DOI: https://doi.org/10.1007/s00330-010-1831-6

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