An exploratory pilot study into the association between microcirculatory parameters derived by MRI-based pharmacokinetic analysis and glucose utilization estimated by PET-CT imaging in head and neck cancer
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To examine the feasibility of deriving quantitative microcirculatory parameters and to investigate the relationship between vascular and metabolic characteristics of head and neck tumours in vivo, using dynamic contrast-enhanced (DCE) MRI and fluorodeoxyglucose (FDG) PET imaging.
Twenty-seven patients with primary squamous cell carcinoma (SCCA) underwent DCE-MRI and combined PET/CT imaging. DCE-MRI data were post-processed by using commercially available software. Transfer constant (K trans), extravascular extracellular blood volume (v e), transfer constant from the extracellular extravascular space to plasma (k ep) and iAUC (initial area under the signal intensity–time curve) were calculated. 3D static PET data were acquired and standardised uptake values (SUV) calculated.
All microcirculatory parameters in tumours were higher than in normal muscle tissue (P ≤ 0.0019). Significant correlations were shown between k ep and K trans (ρ = 0.77), v e and k ep (ρ = −0.7), and iAUC and v e (ρ = 0.53). Significant correlations were observed for SUVmean and v e as well as iAUC (ρ = 0.42 and ρ = 0.66, respectively). SUVmax was significantly correlated with iAUC (ρ = 0.69).
The demonstrated relationships between vascular and metabolic characteristics of primary SCCA imply a complex interaction between vascular delivery characteristics and tumour metabolism. The lack of correlation between SUV and K trans/k ep suggests that both diagnostic techniques may provide complementary information.
KeywordsMagnetic resonance imaging Functional tumour imaging PET-CT imaging Carcinoma Squamous cell Fluorodeoxyglucose F18
- 1.Bisdas S, Baghi M, Smolarz A et al (2007) Quantitative measurements of perfusion and permeability of oropharyngeal and oral cavity cancer, recurrent disease, and associated lymph nodes using first-pass contrast-enhanced computed tomography studies. Invest Radiol 42:172–179CrossRefPubMedGoogle Scholar
- 5.Surlan-Popovic K, Bisdas S, Rumboldt Z et al (2010) Changes in perfusion CT of advanced squamous cell carcinoma of the head and neck treated during the course of concomitant chemoradiotherapy. AJNR Am J Neuroradiol 31:570–575Google Scholar
- 9.Newbold K, Castellano I, Charles-Edwards E et al (2009) An exploratory study into the role of dynamic contrast-enhanced magnetic resonance imaging or perfusion computed tomography for detection of intratumoral hypoxia in head-and-neck cancer. Int J Radiat Oncol Biol Phys 74:29–37PubMedGoogle Scholar
- 16.Seitz O, Chambron-Pinho N, Middendorp M et al (2009) 18F-Fluorodeoxyglucose-PET/CT to evaluate tumor, nodal disease, and gross tumor volume of oropharyngeal and oral cavity cancer: comparison with MR imaging and validation with surgical specimen. Neuroradiology 51:677–686CrossRefPubMedGoogle Scholar