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European Radiology

, Volume 20, Issue 9, pp 2135–2145 | Cite as

Identifying the most infectious lesions in pulmonary tuberculosis by high-resolution multi-detector computed tomography

  • Jun Jun Yeh
  • Solomon Chih-Cheng Chen
  • Wen-Bao Teng
  • Chun-Hsiung Chou
  • Shih-Peng Hsieh
  • Tsung-Lung Lee
  • Ming-Ting WuEmail author
Computed Tomography

Abstract

Objective:

This study aimed to determine whether characteristics detected by multi-detector computed tomography (MDCT) were predictive of highly infectious, smear-positive, active pulmonary tuberculosis (PTB).

Methods:

Among 124 patients with active PTB, 84 had positive (group 1) and 40 had negative (group 2) smear results for acid-fast bacilli. Multiplanar MDCT, axial conventional CT and chest X-ray images were analysed retrospectively for morphology, number, and segmental (lobe) distribution of lesions.

Results:

By multivariate analysis, consolidation over any segment of the upper, middle, or lingual lobes, cavitations, and clusters of nodules were associated with group 1, while centrilobular nodules were predictive of group 2. Using five independent variables associated with risk in group 1, a prediction model was created to distinguish between group 1 and group 2. ROC curve analysis showed an area under the curve of 0.951 ± 0.021 for this prediction model. With the ideal cutoff point score of 1, the sensitivity, specificity, and positive predictive values were 84.5%, 97.5%, and 98.0%, respectively.

Conclusions:

A model to predict smear-positive active PTB on the basis of findings from MDCT may be a useful tool for clinical decisions about isolating patients pending sputum smear results.

Keywords

Patient isolation Tuberculosis Receiver-operating characteristic (ROC) curve Sputum Decision making 

Notes

Acknowledgments

The authors wish to thank Associate Professor Yi-Hsin Yang, Ph.D., of the Department of Medical Research in Kaohsiung Medical University for her assistance with statistical analysis.

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Copyright information

© European Society of Radiology 2010

Authors and Affiliations

  • Jun Jun Yeh
    • 1
    • 2
    • 3
  • Solomon Chih-Cheng Chen
    • 1
    • 4
  • Wen-Bao Teng
    • 1
  • Chun-Hsiung Chou
    • 1
  • Shih-Peng Hsieh
    • 1
  • Tsung-Lung Lee
    • 1
  • Ming-Ting Wu
    • 5
    • 6
    Email author
  1. 1.Pingtung Christian HospitalPingtungTaiwan
  2. 2.Mei-Ho Institute of TechnologyPingtungTaiwan
  3. 3.China Medical UniversityTaichungTaiwan
  4. 4.Institute of Occupational Medicine and Industrial Hygiene, College of Public HealthNational Taiwan UniversityTaipeiTaiwan
  5. 5.Faculty of Medicine, School of MedicineNational Yang Ming UniversityTaipeiTaiwan
  6. 6.Section of Thoracic and Circulation Imaging, Department of RadiologyKaohsiung Veterans General HospitalKaohsiungRepublic of China

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