European Radiology

, Volume 20, Issue 9, pp 2100–2107 | Cite as

Optimisation of contrast medium volume and injection-related factors in CT pulmonary angiography: 64-slice CT study

  • Selma Uysal RamadanEmail author
  • Pınar Kosar
  • Iclal Sonmez
  • Sevilay Karahan
  • Ugur Kosar



To compare the image quality of computed tomography pulmonary angiography (CTPA) obtained with the injection of various low doses of contrast medium (CM) with different injection-related factors.


A total of 90 patients (42 females, 48 males; 54.3 ± 18.6 years) undergoing CTPA were included. Three CM protocols, each containing 30 patients, were created. Protocols 1, 2 and 3 consisted of a CM of 60 ml, 55 ml and 50 ml, and a bolus trigger level of 120 HU, 90 HU and 75 HU, respectively. Injection was uniphasic for protocols 1 and 2 (flow rate 5 ml/s), and biphasic for protocol 3 (flow rates 5 and 4 ml/s); with saline flushing afterwards. Enhancement was measured in three central and six peripheral pulmonary arteries.


The mean attenuation value for pulmonary arteries was over 250 HU for all protocols. There was no difference between the attenuation levels with the protocols (p > 0.05). The percentage of pulmonary arteries exceeding optimal attenuation (≥250 HU) showed that protocols 2 and 3 were 90–100% successful (p < 0.05).


The use of proper injection-related factors during CTPA, such as a low trigger level and a high flow rate with saline injection following a decreased CM volume (55 ml or 50 ml), will enable adequate pulmonary artery contrast enhancement.


Computed tomography Pulmonary embolism Pulmonary artery Computed tomography angiography MSCT 



This study was presented as a scientific exhibit at ECR 2010.


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Copyright information

© European Society of Radiology 2010

Authors and Affiliations

  • Selma Uysal Ramadan
    • 1
    • 3
    Email author
  • Pınar Kosar
    • 1
  • Iclal Sonmez
    • 1
  • Sevilay Karahan
    • 2
  • Ugur Kosar
    • 1
  1. 1.Department of RadiologyAnkara Training and Research HospitalAnkaraTurkey
  2. 2.Department of Biostatistics, Faculty of MedicineHacettepe UniversityAnkaraTurkey
  3. 3.Ankara Training and Research HospitalCebeci, AnkaraTurkey

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