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European Radiology

, Volume 20, Issue 7, pp 1580–1589 | Cite as

Lung volumes, ventricular function and pulmonary arterial flow in children operated on for left-sided congenital diaphragmatic hernia: long-term results

  • Nasreddin AbolmaaliEmail author
  • Arne Koch
  • Knut Götzelt
  • Gabriele Hahn
  • Guido Fitze
  • Christian Vogelberg
Pediatric

Abstract

Objectives

To compare MRI-based functional pulmonary and cardiac measurements in the long-term follow-up of children operated on for left-sided congenital diaphragmatic hernia (CDH) with age- and body size-matched healthy controls.

Methods

Twelve children who received immediate postnatal surgery for closure of isolated left-sided CDH were included and received basic medical examinations, pulmonary function testing and echocardiography. MRI included measurement of lung volume, ventricular function assessment and velocity-encoded imaging of the pulmonary arteries and was compared with the data for 12 healthy children matched for age and body size.

Results

While patients’ clinical test results were not suspicious, comparison between the MRI data for patients and those for healthy controls revealed significant differences. In patients, the volumes of the left lungs were increased and the tidal volume was larger on the right side. While the stroke volumes of both ventricles were reduced, heart rate and ejection fraction were increased. Flow, acceleration time and cross-sectional area of the left pulmonary artery were reduced.

Conclusion

Functional MRI detected pulmonary and cardiac findings in the late follow-up of CDH children which may be missed by standard clinical methods and might be relevant for decisions regarding late outcome and treatment.

Keywords

Lung Ventricular function Congenital diaphragmatic hernia Paediatric MRI 

Notes

Acknowledgements

The authors thank Hanns Ackermann (Institute for Biostatistics and Mathematical Modeling, Johann Wolfgang Goethe University, Frankfurt am Main, Germany) for his assistance with the statistical analysis and Professor Michael Laniado (Chairman of the Institute of Diagnostic Radiology, Medical Faculty Carl Gustav Carus, Dresden University of Technology) for the kind provision of acquisition time. We thank Antje Böhm and Katarina Marx for excellent technical assistance.

This research and the authors were supported by the Federal Ministry of Education and Research, Germany (BMBF contract 03ZIK042).

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Copyright information

© European Society of Radiology 2010

Authors and Affiliations

  • Nasreddin Abolmaali
    • 1
    Email author
  • Arne Koch
    • 1
  • Knut Götzelt
    • 2
  • Gabriele Hahn
    • 3
  • Guido Fitze
    • 4
  • Christian Vogelberg
    • 2
  1. 1.OncoRay - Molecular and Biological Imaging, Medical Faculty Carl Gustav CarusDresden University of TechnologyDresdenGermany
  2. 2.Clinic and Policlinic for Pediatrics - Pediatric PulmonologyUniversity Clinics Carl Gustav Carus, Dresden University of TechnologyDresdenGermany
  3. 3.Institute and Policlinic for Radiology - Pediatric RadiologyUniversity Clinics Carl Gustav Carus, Dresden University of TechnologyDresdenGermany
  4. 4.Clinic and Policlinic for Pediatric SurgeryUniversity Clinics Carl Gustav Carus, Dresden University of TechnologyDresdenGermany

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