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European Radiology

, Volume 20, Issue 7, pp 1563–1571 | Cite as

Computer-aided interpretation of dynamic magnetic resonance imaging reflects histopathology of invasive breast cancer

  • Pascal A. T. BaltzerEmail author
  • Tibor Vag
  • Matthias Dietzel
  • Sebastian Beger
  • Christian Freiberg
  • Mieczyslaw Gajda
  • Oumar Camara
  • Werner A. Kaiser
Breast

Abstract

Objective

To perform a semiautomated software-based comparison of invasive breast carcinoma dynamic enhancement patterns in MR mammography with histological prognostic factors considering whole lesion volumes.

Material and methods

A total of 128 patients with 145 invasive breast carcinomas underwent dynamic MR mammography. Kinetic features from the invasive breast lesions were obtained using commercially available software to automatically assess volume enhancement characteristics of a manually chosen lesion. Findings were compared with histological factors determining tumour aggressiveness (lymph node status, LN; oestrogen/progesterone receptor (ER/PR) status; HER-2/neu status; tumour grade) by using nonparametric rank tests and binary logistic regression analysis (BLRA).

Results

Volume enhancement characteristics were significantly influenced by LN, ER/PR and HER-2/neu status (P < 0.05). BLRA implied that total lesion and plateau voxel volume were independent predictors of ER/PR and HER-2/neu status. Strongest initial enhancement predicted negative ER/PR, and time to peak of the most suspect curve was inversely correlated with positive LN status. On the other hand, no statistical significance could be observed between histological tumour grading and kinetic features.

Conclusion

Histopathological criteria associated with poor prognosis lead to significantly more aggressive dynamic enhancement patterns in MR mammography. In this study, higher lesion volumes as well as higher and earlier initial enhancement were independent covariates predicting higher tumour aggressiveness.

Keywords

Breast Neoplasm MRI DCE-MRI Computer-assisted diagnosis 

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Copyright information

© European Society of Radiology 2010

Authors and Affiliations

  • Pascal A. T. Baltzer
    • 1
    Email author
  • Tibor Vag
    • 1
  • Matthias Dietzel
    • 1
  • Sebastian Beger
    • 1
  • Christian Freiberg
    • 1
  • Mieczyslaw Gajda
    • 2
  • Oumar Camara
    • 3
  • Werner A. Kaiser
    • 1
  1. 1.Institute of Diagnostic and Interventional RadiologyFriedrich Schiller University of JenaJenaGermany
  2. 2.Institute of PathologyFriedrich Schiller University of JenaJenaGermany
  3. 3.Clinic of GynecologyFriedrich Schiller University of JenaJenaGermany

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