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Usefulness of diffusion-weighted MR imaging in the evaluation of pulmonary lesions

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Abstract

Purpose

The role of diffusion-weighted MR imaging (DWI) in the differential diagnosis of pulmonary malignant tumours and solid benign lesions was investigated.

Methods

Sixty-two patients with 66 lesions underwent conventional MRI and DWI (diffusion factor of 0 and 500 s/mm2) examinations with 1.5-T MRI. The signal intensity of DWI images was observed and the apparent diffusion coefficient (ADC) values of the lesions were measured. Statistical analyses were performed with the independent samples t test, Pearson’s chi-square test and receiver operating characteristic (ROC) analysis.

Results

The signal intensities of pulmonary malignant tumours and solid benign lesions were not significantly different, but the ADC value of benign lesions was statistically higher than that of malignant tumours (p = 0.001). By ROC analysis, the optimal threshold of ADC was 1.400 × 10–3 mm2/s and the sensitivity and specificity were 83.3% and 74.1%, respectively. There were statistical differences between small cell carcinoma (SCLC) and non-small cell carcinoma (NSCLC) as well; the former was lower than the latter (p = 0.007).

Conclusion

Our data indicate that quantitative analysis of ADC values may help diagnose or distinguish pulmonary lesions, and it also provides a promising method for characterising the pulmonary masses.

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Authors and Affiliations

  1. Department of Radiology, General Hospital of Tianjin Medical University, Tianjin, China

    Haidong Liu, Ying Liu, Tielian Yu & Ning Ye

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  1. Haidong Liu
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  2. Ying Liu
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  3. Tielian Yu
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  4. Ning Ye
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Correspondence to Tielian Yu.

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Liu, H., Liu, Y., Yu, T. et al. Usefulness of diffusion-weighted MR imaging in the evaluation of pulmonary lesions. Eur Radiol 20, 807–815 (2010). https://doi.org/10.1007/s00330-009-1629-6

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  • DOI: https://doi.org/10.1007/s00330-009-1629-6

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