European Radiology

, 19:975 | Cite as

Consensus report of the 2nd International Forum for Liver MRI

  • Akihiro Tanimoto
  • Jeong Min Lee
  • Takamichi Murakami
  • Alexander Huppertz
  • Masatoshi Kudo
  • Luigi Grazioli


  1. 1.
    Ba–Ssalamah A, Uffmann M, Saini S, Bastati N, Herold C, Schima W (2009) Clinical value of MRI liver-specific contrast agents: a tailored examination for a confident non-invasive diagnosis of focal liver lesions. Eur Radiol 19:342–357CrossRefPubMedGoogle Scholar
  2. 2.
    Reimer P, Schneider G, Schima W (2004) Hepatobiliary contrast agents for contrast-enhanced MRI of the liver: properties, clinical development and applications. Eur Radiol 14:559–578CrossRefPubMedGoogle Scholar
  3. 3.
    Weinmann HJ, Schuhmann-Giampieri G, Schmitt-Willich H, Vogler H, Frenzel T, Gries H (1991) A new lipophilic gadolinium chelate as a tissue-specific contrast medium for MRI. Magn Reson Med 22:233–237CrossRefPubMedGoogle Scholar
  4. 4.
    Hamm B, Staks T, Mühler A, Bollow M, Taupitz M, Frenzel T, Wolf KJ, Weinmann HJ, Lange L (1995) Phase I clinical evaluation of Gd-EOB-DTPA as a hepatobiliary MR contrast agent: safety, pharmacokinetics, and MR imaging. Radiology 195:785–792PubMedGoogle Scholar
  5. 5.
    Shuter B, Tofts PS, Wang SC, Pope JM (1996) The relaxivity of Gd-EOB-DTPA and Gd-DTPA in liver and kidney of the Wistar rat. Magn Reson Imaging 14:243–253CrossRefPubMedGoogle Scholar
  6. 6.
    Rohrer M, Bauer H, Mintorovitch J, Requardt M, Weinmann HJ (2005) Comparison of magnetic properties of MRI contrast media solutions at different magnetic field strengths. Invest Radiol 40:715–724CrossRefPubMedGoogle Scholar
  7. 7.
    Vander Elst L, Maton F, Laurent S, Seghi F, Chapelle F, Muller RN (1997) A multinuclear MR study of Gd-EOB-DTPA: comprehensive preclinical characterization of an organ-specific MRI contrast agent. Magn Reson Med 38:604–614CrossRefPubMedGoogle Scholar
  8. 8.
    Murakami T, Kim T, Oi H, Nakamura H, Igarashi H, Matsushita M, Okamura J, Kozuka T (1995) Detectability of hypervascular hepatocellular carcinoma by arterial phase images of MR and spiral CT. Acta Radiol 36:372–376CrossRefPubMedGoogle Scholar
  9. 9.
    Malone D, Zech CJ, Ayuso C, Bartolozzi C, Jonas E, Tanimoto A (2008) Magnetic resonance imaging of the liver: consensus statement of the 1st Primovist User Meeting. Eur Radiol Suppl 18:849–864CrossRefGoogle Scholar
  10. 10.
    Goudemant JF, Van Beers BE, Demeure R, Grandin C, Delos M, Pringot J (1998) Comparison of unenhanced and gadoxetate disodium-enhanced spin-echo magnetic resonance imaging for the detection of experimental hepatocellular carcinoma in the rat. Invest Radiol 33:80-84CrossRefPubMedGoogle Scholar
  11. 11.
    Khangure MS, Hua J (1996) Comparative assessment of gadoxetate disodium, manganese dipyridoxal diphosphate, and superparamagnetic iron oxide for enhancement of the liver in dogs. Acad Radiol 3(Suppl 2):S458–S460CrossRefGoogle Scholar
  12. 12.
    Schmitz SA, Mühler A, Wagner S, Wolf KJ (1996) Functional hepatobiliary imaging with gadolinium-EOB-DTPA. A comparison of magnetic resonance imaging and 153gadolinium-EOB-DTPA scintigraphy in rats. Invest Radiol 31:154–160CrossRefPubMedGoogle Scholar
  13. 13.
    Segers J, Le Duc G, Laumonier C, Troprès I, Elst LV, Muller RN (2005) Evaluation of Gd-EOB-DTPA uptake in a perfused and isolated mouse liver model: correlation between magnetic resonance imaging and monochromatic quantitative computed tomography. Invest Radiol 40:574–582CrossRefPubMedGoogle Scholar
  14. 14.
    Bluemke DA, Sahani D, Amendola M, Balzer T, Breuer J, Brown JJ, Casalino DD, Davis PL, Francis IR, Krinsky G, Lee FT Jr, Lu D, Paulson EK, Schwartz LH, Siegelman ES, Small WC, Weber TM, Welber A, Shamsi K (2005) Efficacy and safety of MR imaging with liver-specific contrast agent: U.S. multicenter phase-III study. Radiology 237:89–98CrossRefPubMedGoogle Scholar
  15. 15.
    Dahlström N, Persson A, Albiin N, Smedby O, Brismar TB (2007) Contrast-enhanced magnetic resonance cholangiography with Gd-BOPTA and Gd-EOB-DTPA in healthy subjects. Acta Radiol 48:362–368CrossRefPubMedGoogle Scholar
  16. 16.
    Halavaara J, Breuer J, Ayuso C, Balzer T, Bellin MF, Blomqvist L, Carter R, Grazioli L, Hammerstingl R, Huppertz A, Jung G, Krause D, Laghi A, Leen E, Lupatelli L, Marsili L, Martin J, Pretorius ES, Reinhold C, Stiskal M, Stolpen AH (2006) Liver tumor characterization: comparison between liver-specific gadoxetic acid disodium-enhanced MRI and biphasic CT – a multicenter trial. J Comput Assist Tomogr 30:345–354CrossRefPubMedGoogle Scholar
  17. 17.
    Hamm B, Thoeni RF, Gould RG, Bernardino ME, Lüning M, Saini S, Mahfouz AE, Taupitz M, Wolf KJ (1994) Focal liver lesions: characterization with nonenhanced and dynamic contrast material-enhanced MR imaging. Radiology 190:417–423PubMedGoogle Scholar
  18. 18.
    Hammerstingl R, Zangos S, Schwarz W, Rosen T, Bechstein WO, Balzer T, Vogl TJ (2002) Contrast-enhanced MRI of focal liver tumors using a hepatobiliary MR contrast agent: detection and differential diagnosis using Gd-EOB-DTPA-enhanced versus Gd-DTPA-enhanced MRI in the same patient. Acad Radiol 9(Suppl 1):S119–S120CrossRefGoogle Scholar
  19. 19.
    Huppertz A, Balzer T, Blakeborough A, Breuer J, Giovagnoni A, Heinz–Peer G, Laniado M, Manfredi RM, Mathieu DG, Mueller D, Reimer P, Robinson PJ, Strotzer M, Taupitz M, Vogl TJ; European EOB Study Group (2004) Improved detection of focal liver lesions at MR imaging: multicenter comparison of gadoxetic acid-enhanced MR images with intraoperative findings. Radiology 230:266–275CrossRefPubMedGoogle Scholar
  20. 20.
    Huppertz A, Haraida S, Kraus A, Zech CJ, Scheidler J, Breuer J, Helmberger TK, Reiser MF (2005) Enhancement of focal liver lesions at gadoxetic acid-enhanced MR imaging: correlation with histopathologic findings and spiral CT – initial observations. Radiology 234:468–478CrossRefPubMedGoogle Scholar
  21. 21.
    Kacl GM, Hagspiel KD, Marincek B (1997) Focal nodular hyperplasia of the liver: serial MRI with Gd-DOTA, superparamagnetic iron oxide, and Gd-EOB-DTPA. Abdom Imaging 22:264–267CrossRefPubMedGoogle Scholar
  22. 22.
    Reimer P, Rummeny EJ, Shamsi K, Balzer T, Daldrup HE, Tombach B, Hesse T, Berns T, Peters PE (1996) Phase II clinical evaluation of Gd-EOB-DTPA: dose, safety aspects, and pulse sequence. Radiology 199:177–183PubMedGoogle Scholar
  23. 23.
    Reimer P, Rummeny EJ, Daldrup HE, Hesse T, Balzer T, Tombach B, Peters PE (1997) Enhancement characteristics of liver metastases, hepatocellular carcinomas, and hemangiomas with Gd-EOB-DTPA: preliminary results with dynamic MR imaging. Eur Radiol 7:275–280CrossRefPubMedGoogle Scholar
  24. 24.
    Vogl TJ, Kümmel S, Hammerstingl R, Schellenbeck M, Schumacher G, Balzer T, Schwarz W, Müller PK, Bechstein WO, Mack MG, Söllner O, Felix R (1996) Liver tumors: comparison of MR imaging with Gd-EOB-DTPA and Gd-DTPA. Radiology 200:59–67PubMedGoogle Scholar
  25. 25.
    Zech CJ, Herrmann KA, Reiser MF, Schoenberg SO (2007) MR imaging in patients with suspected liver metastases: value of liver-specific contrast agent Gd-EOB-DTPA. Magn Reson Med Sci 6:43–52CrossRefPubMedGoogle Scholar
  26. 26.
    Hammerstingl R, Huppertz A, Breuer J, Balzer T, Blakeborough A, Carter R, Fusté LC, Heinz-Peer G, Judmaier W, Laniado M, Manfredi RM, Mathieu DG, Müller D, Mortelè K, Reimer P, Reiser MF, Robinson PJ, Shamsi K, Strotzer M, Taupitz M, Tombach B, Valeri G, van Beers BE, Vogl TJ; European EOB-study group (2008) Diagnostic efficacy of gadoxetic acid (Primovist)-enhanced MRI and spiral CT for a therapeutic strategy: comparison with intraoperative and histopathologic findings in focal liver lesions. Eur Radiol 18:457–467CrossRefPubMedGoogle Scholar
  27. 27.
    Bae KT, Heiken JP, Brink JA (1998) Aortic and hepatic peak enhancement at CT: effect of contrast medium injection rate–pharmacokinetic analysis and experimental porcine model. Radiology 206:455–464PubMedGoogle Scholar
  28. 28.
    Prince MR (1994) Gadolinium-enhanced MR aortography. Radiology 191:155–164PubMedGoogle Scholar
  29. 29.
    Shinozaki K, Yoshimitsu K, Irie H, Aibe H, Tajima T, Nishie A, Nakayama T, Kakihara D, Shimada M, Honda H (2004) Comparison of test-injection method and fixed-time method for depiction of hepatocellular carcinoma using dynamic steady-state free precession magnetic resonance imaging. J Comput Assist Tomogr 28:628–634CrossRefPubMedGoogle Scholar
  30. 30.
    Foo TK, Saranathan M, Prince MR, Chenevert TL (1997) Automated detection of bolus arrival and initiation of data acquisition in fast, three-dimensional, gadolinium-enhanced MR angiography. Radiology 203:275–280PubMedGoogle Scholar
  31. 31.
    Prince MR, Chenevert TL, Foo TK, Londy FJ, Ward JS, Maki JH (1997) Contrast-enhanced abdominal MR angiography: optimization of imaging delay time by automating the detection of contrast material arrival in the aorta. Radiology 203:109–114PubMedGoogle Scholar
  32. 32.
    Ho VB, Foo TK (1998) Optimization of gadolinium–enhanced magnetic resonance angiography using an automated bolus-detection algorithm (MR SmartPrep). Original investigation. Invest Radiol 33:515–523CrossRefPubMedGoogle Scholar
  33. 33.
    Riedy G, Golay X, Melhem ER (2005) Three-dimensional isotropic contrast-enhanced MR angiography of the carotid artery using sensitivity-encoding and random elliptic centric k-space filling: technique optimization. Neuroradiology 47:668–673CrossRefPubMedGoogle Scholar
  34. 34.
    Svensson J, Petersson JS, Ståhlberg F, Larsson EM, Leander P, Olsson LE (1999) Image artefacts due to a time-varying contrast medium concentration in 3D contrast-enhanced MRA. Magn Reson Imaging 10:919–928CrossRefGoogle Scholar
  35. 35.
    Maki JH, Prince MR, Londy FJ, Chenevert TL (1996) The effects of time varying intravascular signal intensity and k-space acquisition order on three-dimensional MR angiography image quality. J Magn Reson Imaging 6:642–651CrossRefPubMedGoogle Scholar
  36. 36.
    Carr JC, Nemcek AA Jr, Abecassis M, Blei A, Clarke L, Pereles FS, McCarthy R, Finn JP (2003) Preoperative evaluation of the entire hepatic vasculature in living liver donors with use of contrast-enhanced MR angiography and true fast imaging with steady-state precession. J Vasc Interv Radiol 14:441–44937PubMedGoogle Scholar
  37. 37.
    Zech CJ, Vos B, Nordell A, Urich M, Blomqvist L, Breuer J, Reiser MF, Weinmann HJ (2009) Vascular enhancement in early dynamic liver MR imaging in an animal model: comparison of two injection regimen and two different doses Gd-EOB-DTPA (gadoxetic acid) with standard Gd-DTPA. Invest Radiol 44:305–310CrossRefPubMedGoogle Scholar
  38. 38.
    Hany TF, McKinnon GC, Leung DA, Pfammatter T, Debatin JF (1997) Optimization of contrast timing for breath-hold three-dimensional MR angiography. J Magn Reson Imaging 7:551–556CrossRefPubMedGoogle Scholar
  39. 39.
    Dorio PJ, Lee FT Jr, Henseler KP, Pilot M, Pozniak MA, Winter TC 3rd, Shock SA (2003) Using a saline chaser to decrease contrast media in abdominal CT. AJR Am J Roentgenol 180:929–934PubMedGoogle Scholar
  40. 40.
    Haage P, Schmitz-Rode T, Hübner D, Piroth W, Günther RW (2000) Reduction of contrast material dose and artefacts by a saline flush using a double power injector in helical CT of the thorax. AJR Am J Roentgenol 174:1049–1053PubMedGoogle Scholar
  41. 41.
    Orlandini F, Boini S, Iochum-Duchamps S, Batch T, Zhu X, Blum A (2005) Assessment of the use of a saline chaser to reduce the volume of contrast medium in abdominal CT. AJR Am J Roentgenol 187:511–515CrossRefGoogle Scholar
  42. 42.
    Saini, S; Nelson, RC (1995) Technique for MR imaging of the liver. Radiology 197:575–577PubMedGoogle Scholar
  43. 43.
    Kim T, Murakami T, Hasuike Y, Gotoh M, Kato N, Takahashi M, Miyazawa T, Narumi Y, Monden M, Nakamura H (1997) Experimental hepatic dysfunction: evaluation by MRI with Gd-EOB-DTPA. J Magn Reson Imaging 7:683–688CrossRefPubMedGoogle Scholar
  44. 44.
    Runge VM (1998) A comparison of two MR hepatobiliary gadolinium chelates: Gd-BOPTA and Gd-EOB-DTPA. J Comput Assist Tomogr 22:643–650CrossRefPubMedGoogle Scholar
  45. 45.
    Tschirch FT, Struwe A, Petrowsky H, Kakales I, Marincek B, Weishaupt D (2008) Contrast-enhanced MR cholangiography with Gd-EOB-DTPA in patients with liver cirrhosis: visualization of the biliary ducts in comparison with patients with normal liver parenchyma. Eur Radiol 18:1577–1586CrossRefPubMedGoogle Scholar
  46. 46.
    Rofsky NM, Weinreb JC, Ambrosino MM, Safir J, Krinsky G (1996) Comparison between in-phase and opposed-phase T1-weighted breathhold FLASH sequences for hepatic imaging. J Comput Assist Tomogr 20:230–235CrossRefPubMedGoogle Scholar
  47. 47.
    Namasivayam S, Martin DR, Saini S (2007) Imaging of liver metastases: MRI. Cancer Imaging 7:2–9CrossRefPubMedGoogle Scholar
  48. 48.
    Tanimoto A, Yuasa Y, Jinzaki M, Nakatsuka S, Takeda T, Kurata T, Shinmoto H, Kuribayashi S (2002) Routine MR imaging protocol with breath-hold fast scans: diagnostic efficacy for focal liver lesions. Radiat Med 20:169–179PubMedGoogle Scholar
  49. 49.
    Ramalho M, Altun E, Herédia V, Zapparoli M, Semelka R (2007) Liver MR imaging: 1.5T versus 3T. Magn Reson Imaging Clin N Am 15:321–347CrossRefPubMedGoogle Scholar
  50. 50.
    Schindera ST, Merkle EM, Dale BM, Delong DM, Nelson RC (2006) Abdominal magnetic resonance imaging at 3.0 T. What is the ultimate gain in signal-to-noise ratio? Acad Radiol 13:1236–1243CrossRefPubMedGoogle Scholar
  51. 51.
    von Falkenhausen MM, Lutterbey G, Morakkabati-Spitz N, Walter O, Gieseke J, Blömer R, Willinek WA, Schild HH, Kuhl CK (2006) High-field-strength MR imaging of the liver at 3.0 T: intraindividual comparative study with MR imaging at 1.5 T. Radiology 241:156–166CrossRefGoogle Scholar
  52. 52.
    Tsurusaki M, Semelka RC, Zapparoli M, Elias J Jr, Altun E, Pamuklar E, Sugimura K (2008) Quantitative and qualitative comparison of 3.0T and 1.5T MR imaging of the liver in patients with diffuse parenchymal liver disease. Eur J Radiol Sep 12Google Scholar
  53. 53.
    Asbach P, Warmuth C, Stemmer A, Rief M, Huppertz A, Hamm B, Taupitz M, Klessen C (2008) High spatial resolution T1-weighted MR imaging of liver and biliary tract during uptake phase of a hepatocyte-specific contrast medium. Invest Radiol 43:809–915CrossRefPubMedGoogle Scholar
  54. 54.
    Casarella WJ, Knowles DM, wolff M, Johnson PM (1978) Focal nodular hyperplasia and liver cell adenoma: radiologic and pathologic differentiation. AJR Am J Roentgenol 131:393–402PubMedGoogle Scholar
  55. 55.
    Paradis V, Benzekri A, Dargère D, Bièche I, Laurendeau I, Vilgrain V, Belghiti J, Vidaud M, Degott C, Bedossa P (2004) Telangiectatic focal nodular hyperplasia: a variant of hepatocellular adenoma. Gastroenterology 126:1323–1329CrossRefPubMedGoogle Scholar
  56. 56.
    Mortelé KJ, Praet M, Van Vlierberghe H, Kunnen M, Ros PR (2000) CT and MR imaging findings in focal nodular hyperplasia of the liver: radiologic–pathologic correlation. AJR Am J Roentgenol 175:687–692PubMedGoogle Scholar
  57. 57.
    Zech CJ, Grazioli L, Breuer J, Reiser MF, Schoenberg SO (2008) Diagnostic performance and description of morphological features of focal nodular hyperplasia in Gd-EOB-DTPAenhanced liver magnetic resonance imaging: results of a multicenter trial. Invest Radiol 43:504–511CrossRefPubMedGoogle Scholar
  58. 58.
    Giovagnoli O, Hein M, Terracciano L, Bongartz G, Ledermann HP (2008) MRI of hepatic adenomatosis: initial observations with gadoxetic acid contrast agent in three patients. AJR 190:W290-W293CrossRefGoogle Scholar
  59. 59.
    Grazioli L, Morana G, Kirchin MA, Schneider G. (2005) Accurate differentiation of focal nodular hyperplasia from hepatic adenoma at gadobenate dimeglumine-enhanced MR imaging: prospective study. Radiology 236:166–177CrossRefPubMedGoogle Scholar
  60. 60.
    Oudkerk M, Torres CG, Song B, König M, Grimm J, Fernandez-Cuadrado J, Op de Beeck B, Marquardt M, van Dijk P, de Groot JC (2002) Characterization of liver lesions with mangafodipir trisodium-enhanced MR imaging: multicenter study comparing MR and dual-phase spiral CT. Radiology 223:517–524CrossRefPubMedGoogle Scholar
  61. 61.
    Matsui O, Kadoya M, Kameyama T, Yoshikawa J, Takashima T, Nakanuma Y, Unoura M, Kobayashi K, Izumi R, Ida M, Kitagawa K (1991) Benign and malignant nodules in cirrhotic livers: distinction based on blood supply. Radiology 178:493–497PubMedGoogle Scholar
  62. 62.
    Hayashi M, Matsui O, Ueda K, Kawamori Y, Kadoya M, Yoshikawa J, Gabata T, Takashima T, Nonomura A, Nakanuma Y (1999) Correlation between the blood supply and grade of malignancy of hepatocellular nodules associated with liver cirrhosis: evaluation by CT during intraarterial injection of contrast medium. AJR Am J Roentgenol 172:969–976PubMedGoogle Scholar
  63. 63.
    Matsui O, Kadoya M, Kameyama T, Yoshikawa J, Arai K, Gabata T, Takashima T, Nakanuma Y, Terada T, Ida M (1989) Adenomatous hyperplastic nodules in the cirrhotic liver: differentiation from hepatocellular carcinoma with MR imaging. Radiology 173:123–126PubMedGoogle Scholar
  64. 64.
    Imai Y, Murakami T, Yoshida S, Nishikawa M, Ohsawa M, Tokunaga K, Murata M, Shibata K, Zushi S, Kurokawa M, Yonezawa T, Kawata S, Takamura M, Nagano H, Sakon M, Monden M, Wakasa K, Nakamura H (2000) Superparamagnetic iron oxide-enhanced magnetic resonance images of hepatocellular carcinoma: correlation with histological grading. Hepatology 32:205–212CrossRefPubMedGoogle Scholar
  65. 65.
    Lim JH, Choi D, Cho SK, Kim SH, Lee WJ, Lim HK, Park CK, Paik SW, Kim YI (2001) Conspicuity of hepatocellular nodular lesions in cirrhotic livers at ferumoxides-enhanced MR imaging: importance of Kupffer cell number. Radiology 220:669–676CrossRefPubMedGoogle Scholar
  66. 66.
    Suzuki S, Iijima H, Moriyasu F, Sasaki S, Yanagisawa K, Miyahara T, Oguma K, Yoshida M, Horibe T, Ito N, Kakizaki D, Abe K, Tsuchiya K (2004) Differential diagnosis of hepatic nodules using delayed parenchymal phase imaging of Levovist contrast ultrasound: comparative study with SPIO-MRI. Hepatol Res 29:122–126CrossRefPubMedGoogle Scholar
  67. 67.
    Lim JH, Lee SJ, Lee WJ, Lim HK, Choo SW, Choo IW (1999) Iodized oil retention due to postbiopsy arterioportal shunt: a false positive lesion in the investigation of hepatocellular carcinoma. Abdom Imaging 24:165–170CrossRefPubMedGoogle Scholar
  68. 68.
    Peterson MS, Baron RL, Marsh JW Jr, Oliver JH 3rd, Confer SR, Hunt LE (2000) Pretransplantation surveillance for possible hepatocellular carcinoma in patients with cirrhosis: epidemiology and CT-based tumor detection rate in 430 cases with surgical pathologic correlation. Radiology 217:743–749PubMedGoogle Scholar
  69. 69.
    Kudo M, Okanoue T; Japan Society of Hepatology (2007) Management of hepatocellular carcinoma in Japan: consensus-based clinical practice manual proposed by the Japan Society of Hepatology. Oncology 72(Suppl 1):2–15CrossRefPubMedGoogle Scholar
  70. 70.
    Roncalli M, Borzio M, Di Tommaso L (2008) Hepatocellular dysplastic nodules. Ann Ital Chir 79:81–89PubMedGoogle Scholar
  71. 71.
    di Martino M, Marin D, Guerrisi A, Geiger D, Galati F, Catalano C (2008) Detection of hepatocellular carcinoma (HCC) in patients with cirrhosis: intraindividual comparison of gadoxetic acid (GD-EOB-DTPA)-enhanced MR imaging and multiphasic 64-slice CT [abstract ssa07-07]. Radiological Society of North AmericaGoogle Scholar
  72. 72.
    Bruix J, Sherman M, Llovet JM, Beaugrand M, Lencioni R, Burroughs AK, Christensen E, Pagliaro L, Colombo M, Rodés J; EASL Panel of Experts on HCC. Clinical management of hepatocellular carcinoma (2001). Conclusions of the Barcelona – 2000 EASL conference. J Hepatol 35:421–430CrossRefPubMedGoogle Scholar
  73. 73.
    Bruix J, Sherman M; Practice Guidelines Committee, American Association for the Study of Liver Diseases (2005) Management of hepatocellular carcinoma. Hepatology 42:1208–1236CrossRefPubMedGoogle Scholar
  74. 74.
    Okita K (2006) Clinical aspects of hepatocellular carcinoma in Japan. Intern Med 45:229–233CrossRefPubMedGoogle Scholar
  75. 75.
    Hori M, Murakami T, Oi H, Kim T, Takahashi S, Matsushita M, Tomoda K, Narumi Y, Kadowaki K, Nakamura H (1998) Sensitivity in detection of hypervascular hepatocellular carcinoma by helical CT with intraarterial injection of contrast medium, and by helical CT and MR imaging with intravenous injection of contrast medium. Acta Radiol 39:144–151CrossRefPubMedGoogle Scholar
  76. 76.
    Sontum PC (2008) Physicochemical characteristics of Sonazoid, a new contrast agent for ultrasound imaging. Ultrasound Med Biol 34:824–833CrossRefPubMedGoogle Scholar
  77. 77.
    Hatanaka K, Kudo M, Minami Y, Ueda T, Tatsumi C, Kitai S, Takahashi S, Inoue T, Hagiwara S, Chung H, Ueshima K, Maekawa K (2008) Differential diagnosis of hepatic tumors: value of contrast-enhanced harmonic sonography using the newly developed contrast agent, Sonazoid. Intervirology 51(Suppl 1):61–69CrossRefPubMedGoogle Scholar
  78. 78.
    Maruyama H, Takahashi M, Ishibashi H, Okugawa H, Okabe S, Yoshikawa M, Yokosuka O (2008) Ultrasound-guided treatments under low acoustic power contrast harmonic imaging for hepatocellular carcinomas undetected by B-mode ultrasonography. Liver Int Sep 18Google Scholar
  79. 79.
    Luo W, Numata K, Morimoto M, Nozaki A, Nagano Y, Sugimori K, Zhou X, Tanaka K (2008) Clinical utility of contrast-enhanced three-dimensional ultrasound imaging with Sonazoid: findings on hepatocellular carcinoma lesions. Eur J Radiol Oct 17Google Scholar
  80. 80.
    di Martino M, Marin D, Guerrisi A, Geiger D, Catalano C, Passariello R (2009) Intraindividual comparison of gadoxetic acid (Gd-EOB-DTPA) enhanced MR imaging and multiphasic 64-slice CT for the detection of hepatocellular carcinoma (HCC) in patients with cirrhosis [abstract B-096]. Proceedings of the European Congress of Radiology, Vienna, AustriaGoogle Scholar
  81. 81.
    Kim SH, Kim SH, Lee J, Kim MJ, Jeon YH, Park Y, Choi D, Lee WJ, Lim HK (2009) Gadoxetic acid-enhanced MRI versus triple-phase MDCT for the preoperative detection of hepatocellular carcinoma. AJR Am J Roentgenol 192:1675–161CrossRefPubMedGoogle Scholar
  82. 82.
    Harris JP, Nelson RC (2004) Abdominal Imaging with multidetector computed tomography: State of the art. J Comput Assist Tomogr 28(Suppl 1):S17–S19CrossRefGoogle Scholar
  83. 83.
    Leoni S, Piscaglia F, Righini R, Bolondi L (2006) Management of small hepatocellular carcinoma. Acta Gastroenterol Belg 69:230–235PubMedGoogle Scholar
  84. 84.
    Ridgway PE, Darzi AW (2003) The role of total mesorectal excision in the management of rectal cancer. Cancer Control 10:205–211PubMedGoogle Scholar
  85. 85.
    Engelen SM, Beets GL, Beets-Tan RG (2007) Role of preoperative local and distant staging in rectal cancer. Onkologie 30:141–145CrossRefPubMedGoogle Scholar
  86. 86.
    Beets-Tan RG, Beets GL, Vliegen RF, Kessels AG, Van Boven H, De Bruine A, von Meyenfeldt MF, Baeten CG, van Engelshoven JM (2001) Accuracy of magnetic resonance imaging in prediction of tumour-free resection margin in rectal cancer surgery. Lancet 357:497–504CrossRefPubMedGoogle Scholar
  87. 87.
    Oberholzer K, Junginger T, Kreitner KF, Krummenauer F, Simiantonaki N, Trouet S, Thelen M (2005) Local staging of rectal carcinoma and assessment of the circumferential resection margin with high–resolution MRI using an integrated parallel acquisition technique. J Magn Reson Imaging 22:101–108CrossRefPubMedGoogle Scholar
  88. 88.
    Mühler A, Clément O, Vexler V, Berthezène Y, Rosenau W, Brasch RC (1992) Hepatobiliary enhancement with Gd-EOB-DTPA: comparison of spin-echo and STIR imaging for detection of experimental liver metastases. Radiology 184:207–213PubMedGoogle Scholar
  89. 89.
    Stern W, Schick F, Kopp AF, Reimer P, Shamsi K, Claussen CD, Laniado M (2000) Dynamic MR imaging of liver metastases with Gd-EOB-DTPA. Acta Radiol 41:255–262CrossRefPubMedGoogle Scholar
  90. 90.
    Ferris JV, Marsh JW, Little AF (1995) Presurgical evaluation of the liver transplant candidate. Radiol Clin North Am 33:497–520PubMedGoogle Scholar
  91. 91.
    Rosenbaum SJ, Stergar H, Antoch G, Veit P, Bockisch A, Kühl H (2006) Staging and follow-up of gastrointestinal tumors with PET/CT. Abdom Imaging 31:25–35CrossRefPubMedGoogle Scholar
  92. 92.
    Mang T, Graser A, Schima W, Maier A (2007) CT colonography: techniques, indications, findings. Eur J Radiol 61:388–399CrossRefPubMedGoogle Scholar
  93. 93.
    Tunaci M (2004) Multidetector row CT of the pancreas. Eur J Radiol 52:18–30CrossRefPubMedGoogle Scholar
  94. 94.
    Freelove R, Walling AD (2006) Pancreatic cancer: diagnosis and management. Am Fam Physician 73:485–492PubMedGoogle Scholar
  95. 95.
    Hricak H, Choyke PL, Eberhardt SC, Leibel SA, Scardino PT (2007) Imaging prostate cancer: a multidisciplinary perspective. Radiology 243:28–53CrossRefPubMedGoogle Scholar
  96. 96.
    Glick SJ (2007) Breast CT. Annu Rev Biomed Eng 9:501–526CrossRefPubMedGoogle Scholar

Copyright information

© European Society of Radiology 2009

Authors and Affiliations

  • Akihiro Tanimoto
    • 1
  • Jeong Min Lee
    • 2
  • Takamichi Murakami
    • 3
  • Alexander Huppertz
    • 4
  • Masatoshi Kudo
    • 5
  • Luigi Grazioli
    • 6
  1. 1.Department of Diagnostic RadiologyKeio University School of MedicineTokyoJapan
  2. 2.Department of RadiologySeoul National University HospitalSeoulKorea
  3. 3.Department of RadiologyKinki University School of MedicineOsakaJapan
  4. 4.Imaging Science Institute Charité, BerlinBerlinGermany
  5. 5.Department of Gastroenterology and HepatologyKinki University School of MedicineOsakaJapan
  6. 6.Department of Radiology, Civic Hospital of BresciaUniversity of BresciaBresciaItaly

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