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Prognostic value of computed tomography coronary angiography in patients with suspected coronary artery disease: a 24-month follow-up study

European Radiology volume 19, pages 1653–1660 (2009)Cite this article

Abstract

The aim of this study was to determine the predictive value of 64-slice computed tomography coronary angiography (CTCA) for major cardiac events in patients with suspected coronary artery disease (CAD). A total of 187 consecutive patients (119 men, age 62.5 ± 10.5 years) without known heart disease underwent single-source 64-slice CTCA (Somatom Sensation 64, Siemens) for clinical suspicion of CAD. Patients underwent follow-up for the occurrence of cardiac death, nonfatal myocardial infarction, unstable angina and cardiac revascularization. In total, 2,822 coronary segments were assessed. Forty-two segments (1.5%) were not assessable because of insufficient image quality. Overall, CTCA revealed absence of CAD in 65 (34.7%) patients, nonobstructive CAD (coronary plaque ≤50%) in 87 (46.5%) patients and obstructive CAD (>50%) in 35 (18.8%) patients. A total of 20 major cardiac events (3 myocardial infarctions, 16 cardiac revascularizations, 1 unstable angina) occurred during a mean follow-up of 24 months. One noncardiac death occurred. Seventeen events occurred in the group of patients with obstructive CAD and three events occurred in the group of nonobstructive CAD. The event rate was 0% among patients with normal coronary arteries at CTCA. CTCA has a 100% negative predictive value for major cardiac events at 24-month follow-up in patients with normal coronary arteries.

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Affiliations

  1. Department of Radiology and Cardiology, Azienda Ospedaliero-Universitaria, Parma, Italy

    Annachiara Aldrovandi, Erica Maffei, Alessandro Palumbo, Sara Seitun, Chiara Martini, Livia Ruffini, Girolamo Crisi, Diego Ardissino & Filippo Cademartiri

  2. Department of Radiology and Cardiology, Erasmus Medical Center, Rotterdam, The Netherlands

    Alessandro Palumbo, Annick C. Weustink, Nico R. Mollet, Pim J. de Feyter, Gabriel P. Krestin & Filippo Cademartiri

  3. Cardiovascular Prevention and Rehabilitation Unit, Don Gnocchi ONLUS, University of Parma, Parma, Italy

    Valerio Brambilla

  4. Department of Cardiology, Ospedale di Carrara, Carrara, Italy

    Alessandra Zuccarelli

  5. Department of Cardiology, University of Padua, Padua, Italy

    Giuseppe Tarantini

  6. Department of Radiology, c/o Piastra Tecnica - Piano 0 - CT Section, Azienda Ospedaliero-Universitaria di Parma, via Gramsci, 14, 43100, Parma, Italy

    Filippo Cademartiri

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  1. Annachiara Aldrovandi
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  2. Erica Maffei
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  4. Sara Seitun
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  7. Alessandra Zuccarelli
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  8. Giuseppe Tarantini
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  9. Annick C. Weustink
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  10. Nico R. Mollet
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  11. Livia Ruffini
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  12. Girolamo Crisi
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  13. Diego Ardissino
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  14. Pim J. de Feyter
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  15. Gabriel P. Krestin
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  16. Filippo Cademartiri
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Correspondence to Filippo Cademartiri.

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Aldrovandi, A., Maffei, E., Palumbo, A. et al. Prognostic value of computed tomography coronary angiography in patients with suspected coronary artery disease: a 24-month follow-up study. Eur Radiol 19, 1653–1660 (2009). https://doi.org/10.1007/s00330-009-1344-3

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  • DOI: https://doi.org/10.1007/s00330-009-1344-3

Keywords

  • Computed tomography coronary angiography
  • Prognosis
  • Suspected coronary artery disease
  • Prognostic value
  • Midterm