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Coronary CT angiography using 64 detector rows: methods and design of the multi-centre trial CORE-64

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Abstract

Multislice computed tomography (MSCT) for the noninvasive detection of coronary artery stenoses is a promising candidate for widespread clinical application because of its non-invasive nature and high sensitivity and negative predictive value as found in several previous studies using 16 to 64 simultaneous detector rows. A multi-centre study of CT coronary angiography using 16 simultaneous detector rows has shown that 16-slice CT is limited by a high number of nondiagnostic cases and a high false-positive rate. A recent meta-analysis indicated a significant interaction between the size of the study sample and the diagnostic odds ratios suggestive of small study bias, highlighting the importance of evaluating MSCT using 64 simultaneous detector rows in a multi-centre approach with a larger sample size. In this manuscript we detail the objectives and methods of the prospective “CORE-64” trial (“Coronary Evaluation Using Multidetector Spiral Computed Tomography Angiography using 64 Detectors”). This multi-centre trial was unique in that it assessed the diagnostic performance of 64-slice CT coronary angiography in nine centres worldwide in comparison to conventional coronary angiography. In conclusion, the multi-centre, multi-institutional and multi-continental trial CORE-64 has great potential to ultimately assess the per-patient diagnostic performance of coronary CT angiography using 64 simultaneous detector rows.

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Acknowledgments

This work was supported in part by the Doris Duke Charitable Foundation (Julie Miller, Clinical Scientist Development Program).

Conflicts of interest

(Other authors: none reported)

Marc Dewey:

Research grants: Amersham Buchler (now: GE Healthcare Biosciences), Bracco-Altana, and Toshiba Medical Systems.

Speakers Bureau: Toshiba Medical Systems and Schering (now: Bayer).

Workshops: www.herz-kurs.de

Narinder Paul:

Research grants: Toshiba Medical Systems.

John Hoe:

Research grants: Toshiba Medical Systems.

Speakers Bureau: Toshiba Medical Systems and GE Healthcare Biosciences.

Workshops: regional training centre for cardiac CT for Toshiba users.

Pedro Lemos:

Consulting fee/Advisory Board: Scietch, Boston Scientific.

Honoraria for lectures: Boston Scientific, Biotronik, Cordis.

Albert Lardo:

Research grants: Toshiba Medical Systems, Medrad.

Speakers Bureau: Toshiba Medical Systems.

Consulting fee: Medrad.

Julie M. Miller:

Research grants: Dr. Miller was primarily funded by the Doris Duke Foundation during the entire study but is also funded in part by a grant from Toshiba Medical Systems and NHLBI.

Armin Arbab-Zadeh:

Speakers Bureau: Toshiba Medical Systems.

Narinder Paul:

Research grants: Toshiba Medical Systems.

Speakers Bureau: Toshiba Medical Systems.

Advisory Board: Vital Images, Inc.

David Bush:

Research grants: Toshiba Medical Systems.

Speakers Bureau: Toshiba Medical Systems, Bristol-Myers Squibb and Sanofi-Adventis.

João A. C. Lima:

Research grants: Principal Investigator of the grant from Toshiba Medical Systems that funded all Core64 activities based at the Johns Hopkins Hospital.

Speakers Bureau: Toshiba Medical Systems, Siemens Medical Systems, GE Medical Systems as well as Bracco Inc., Astellas Inc. and Abbott Laboratories.

Author information

Authors and Affiliations

  1. Department of Medicine, Division of Cardiology, Johns Hopkins Hospital, Johns Hopkins University, 600 N. Wolfe Street, Blalock 536, Baltimore, MD, USA

    Julie M. Miller, Andrea L. Vavere, Armin Arbab-Zadeh, David E. Bush, Albert C. Lardo, John Texter, Jeffery Brinker & João A. C. Lima

  2. Department of Radiology, Charité - Universitätsmedizin Berlin, Medical School, Humboldt-Universität und Freie Universität zu Berlin, Charitéplatz 1, 10117, Berlin, PO Box 10098, Germany

    Marc Dewey

  3. Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil

    Carlos E. Rochitte & Pedro A. Lemos

  4. Department of Cardiology, Iwate Medical University, Morioka, Japan

    Hiroyuki Niinuma

  5. Department of Medical Imaging, Toronto General Hospital, Toronto, Canada

    Narinder Paul

  6. Medi-Rad Associates Ltd, CT Centre, Mt Elizabeth Hospital, Singapore, Singapore

    John Hoe

  7. Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands

    Albert de Roos

  8. Department of Radiology, Iwate Medical University, Morioka, Japan

    Kunihiro Yoshioka

  9. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA

    Christopher Cox

  10. Department of Radiology, Beth Israel Deaconess, Harvard University, Boston, MA, USA

    Melvin E. Clouse

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  1. Julie M. Miller
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  2. Marc Dewey
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  3. Andrea L. Vavere
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  4. Carlos E. Rochitte
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  5. Hiroyuki Niinuma
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  6. Armin Arbab-Zadeh
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  7. Narinder Paul
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  8. John Hoe
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  9. Albert de Roos
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  10. Kunihiro Yoshioka
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  11. Pedro A. Lemos
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  13. Albert C. Lardo
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  14. John Texter
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  15. Jeffery Brinker
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  16. Christopher Cox
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  17. Melvin E. Clouse
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  18. João A. C. Lima
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Corresponding authors

Correspondence to Julie M. Miller or Marc Dewey.

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J.M. Miller and M. Dewey contributed equally to this work.

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Miller, J.M., Dewey, M., Vavere, A.L. et al. Coronary CT angiography using 64 detector rows: methods and design of the multi-centre trial CORE-64. Eur Radiol 19, 816–828 (2009). https://doi.org/10.1007/s00330-008-1203-7

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