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Coronary 64-slice CT angiography predicts outcome in patients with known or suspected coronary artery disease

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Abstract

The aim of this study was to assess the prognostic value of 64-slice CT angiography (CTA) in patients with known or suspected coronary artery disease (CAD). Sixty-four-slice coronary CTA was performed in 220 patients [mean age 63 ± 11 years, 77 (35%) female] with known or suspected CAD. CTA images were analyzed with regard to the presence and number of coronary lesions. Patients were followed-up for the occurrence of the following clinical endpoints: death, nonfatal myocardial infarction, unstable angina, and coronary revascularization. During a mean follow-up of 14 ± 4 months, 59 patients (27%) reached at least one of the predefined clinical endpoints. Patients with abnormal coronary arteries on CTA (i.e., presence of coronary plaques) had a 1st-year event rate of 34%, whereas in patients with normal coronary arteries no events occurred (event rate, 0%, p < 0.001). Similarly, obstructive lesions (≥50% luminal narrowing) on CTA were associated with a high first-year event rate (59%) compared to patients without stenoses (3%, p < 0.001). The presence of obstructive lesions was a significant independent predictor of an adverse cardiac outcome. Sixty-four-slice CTA predicts cardiac events in patients with known or suspected CAD. Conversely, patients with normal coronary arteries on CTA have an excellent mid-term prognosis.

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Abbreviations

CT:

computed tomography

CTA:

CT angiography

CA:

coronary angiography

CAD:

coronary artery disease

SPECT:

single photon emission computed tomography

CCS:

coronary calcium score

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Acknowledgements

This study was supported by a grant from the Swiss National Science Foundation (SNSF-professorship grant no. PP00A-68835) and by a grant from the National Center of Competence in Research, Computer-Aided and Image-Guided Medical Interventions (NCCR CO-ME) of the Swiss National Science Foundation. We are grateful to our Deputy Chief Radiographer Ratko Milovanovic for his excellent technical support.

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Authors and Affiliations

  1. Cardiovascular Center, University Hospital Zurich NUK C 32, Ramistrasse 100, CH-8091, Zurich, Switzerland

    Oliver Gaemperli, Ines Valenta, Tiziano Schepis & Philipp A. Kaufmann

  2. Institute of Diagnostic Radiology, University Hospital Zurich, Ramistrasse 100, CH-8091, Zurich, Switzerland

    Lars Husmann, Hans Scheffel, Lotus Desbiolles, Sebastian Leschka & Hatem Alkadhi

  3. Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich, Ramistrasse 71, CH-8006, Zurich, Switzerland

    Philipp A. Kaufmann

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  1. Oliver Gaemperli
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  2. Ines Valenta
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  3. Tiziano Schepis
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  4. Lars Husmann
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  7. Sebastian Leschka
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  8. Hatem Alkadhi
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  9. Philipp A. Kaufmann
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Correspondence to Oliver Gaemperli.

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Gaemperli, O., Valenta, I., Schepis, T. et al. Coronary 64-slice CT angiography predicts outcome in patients with known or suspected coronary artery disease. Eur Radiol 18, 1162–1173 (2008). https://doi.org/10.1007/s00330-008-0871-7

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  • DOI: https://doi.org/10.1007/s00330-008-0871-7

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