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A comparison of tumour perfusion assessed by deconvolution-based analysis of dynamic contrast-enhanced CT and MR imaging in patients with squamous cell carcinoma of the upper aerodigestive tract

European Radiology volume 18, pages 843–850 (2008)Cite this article

Abstract

Our aim was to compare the perfusion [blood flow (BF)] values obtained by first-pass dynamic contrast-enhanced (DCE) T2-weighted magnetic resonance (MR) and computed tomography (CT) imaging of squamous cell carcinoma (SCC) in the upper aerodigestive tract in the same patient population. Seventeen patients with histologically proven primary SCC of the upper aerodigestive tract were prospectively evaluated. The perfusion CT studies were obtained using a 16-row multi-slice CT scanner running a commercial software package with a deconvolution-based technique; while the perfusion MR studies (1.5 T) were analysed with in-house-written MR perfusion software based also on a deconvolution technique. The mean perfusion values of SCC assessed by perfusion CT and MR imaging were 68.93 ± 31.61 and 81.56 ± 49.25 ml/min/100 g, respectively. The Bland-Altman graph showed a proportional error in the perfusion values measured by DCE-CT and -MR imaging; however, the degree of agreement was acceptable (95% limits of agreement: −66.1 to 40.8). Regression analysis of the perfusion values demonstrated significant correlation between the modalities: BFMR = 1.34 × BFCT – 10.93 (P < 0.0005, r 2 = 0.74). The parametric maps generated by both modalities provided insights into the tumour perfusion, while analysis of the obtained perfusion values demonstrated that both modalities may be used interchangeably in SCC in the upper aerodigestive tract.

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Authors and Affiliations

  1. Department of Diagnostic and Interventional Radiology, Johann Wolfgang University Hospital, Theodor Stern Kai 7, 60590, Frankfurt, Germany

    Sotirios Bisdas, Leon Medov & Thomas J. Vogl

  2. Department of Otorhinolaryngology, Head and Neck Surgery, Johann Wolfgang University Hospital, Frankfurt, Germany

    Mehran Baghi & Jens Wagenblast

  3. 401 Military Hospital, Athens, Greece

    George N. Konstantinou

  4. Department of Oncologic Imaging, National Cancer Center, Singapore, Singapore

    Choon Hua Thng

  5. School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore, Singapore

    Tong San Koh

Authors
  1. Sotirios Bisdas
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  2. Leon Medov
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  3. Mehran Baghi
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  4. George N. Konstantinou
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  5. Jens Wagenblast
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  6. Choon Hua Thng
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  7. Thomas J. Vogl
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  8. Tong San Koh
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Correspondence to Sotirios Bisdas.

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Bisdas, S., Medov, L., Baghi, M. et al. A comparison of tumour perfusion assessed by deconvolution-based analysis of dynamic contrast-enhanced CT and MR imaging in patients with squamous cell carcinoma of the upper aerodigestive tract. Eur Radiol 18, 843–850 (2008). https://doi.org/10.1007/s00330-007-0827-3

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  • DOI: https://doi.org/10.1007/s00330-007-0827-3

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