European Radiology

, Volume 18, Issue 4, pp 731–737 | Cite as

Volume doubling time and growth rate of renal cell carcinoma determined by helical CT: a single-institution experience

  • Ji Young Lee
  • Chan Kyo KimEmail author
  • Dongil Choi
  • Byung Kwan Park


The purpose of this study was to retrospectively evaluate the volume doubling time (VDT) and growth rate of renal cell carcinomas (RCC) on a serial computed tomography (CT) scan. Thirty pathologically proven RCCs were reviewed with helical CT. Each tumor underwent at least two CT scans. Tumor volume was determined using an area measuring tool and the summation-of-areas technique. Growth rate was evaluated in terms of diameter and volume changes. VDT and volume growth rate were compared in relation to several factors (initial diameter, initial volume, diameter growth rate, volume growth rate, tumor grade, tumor subtype, sex or age). Mean VDT of RCCs was 505 days. Mean diameter and volume growth rate were 0.59 cm/year and 19.1 cm3/year, respectively. For volume and diameter growth rate, tumors ≤4 cm showed lower rates than those >4 cm (P < 0.01). VDT was weakly negatively correlated with diameter growth rate (P > 0.05). Volume growth rate was moderately to strongly positively correlated with initial diameter, initial volume and diameter growth rate (P < 0.05). In conclusion, small RCCs grew at a slow rate both diametrically and volumetrically. More accurate assessment of tumor growth rate and VDT may be helpful to understand the natural history of RCC.


Renal cell carcinoma Natural history Follow-up studies CT Growth rate 


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Copyright information

© European Society of Radiology 2007

Authors and Affiliations

  • Ji Young Lee
    • 1
  • Chan Kyo Kim
    • 1
    Email author
  • Dongil Choi
    • 1
  • Byung Kwan Park
    • 1
  1. 1.Department of Radiology and Center for Imaging Science, Samsung Medical CenterSungkyunkwan University School of MedicineSeoulSouth Korea

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