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European Radiology

, Volume 18, Issue 4, pp 723–730 | Cite as

The utility of diffusion-weighted MR imaging for differentiating uterine sarcomas from benign leiomyomas

  • Ken Tamai
  • Takashi KoyamaEmail author
  • Tsuneo Saga
  • Nobuko Morisawa
  • Koji Fujimoto
  • Yoshiki Mikami
  • Kaori Togashi
Urogenital

Abstract

The usefulness of diffusion-weighted (DW) magnetic resonance (MR) imaging for the diagnosis of uterine sarcomas was investigated, as well as whether DW images and quantitative measurement of apparent diffusion coefficient (ADC) values can facilitate differentiating uterine sarcomas from benign leiomyomas. MR images including DW images were obtained in 43 surgically treated patients with 58 myometrial tumors, including seven uterine sarcomas (five leiomyosarcomas and two endometrial stromal sarcomas) and 51 benign leiomyomas (43 ordinary leiomyomas, two cellular leiomyomas and six degenerated leiomyomas). Qualitative analysis of non-enhanced and postcontrast MR images and DW images and quantitative measurement of ADC values were performed for each myometrial tumor. Both uterine sarcomas and cellular leiomyomas exhibited high signal intensity on DW images, whereas ordinary leiomyomas and most degenerated leiomyomas showed low signal intensity. The mean ADC value (10−3 mm2/s) of sarcomas was 1.17 ± 0.15, which was lower than those of the normal myometrium (1.62 ± 0.11) and degenerated leiomyomas (1.70 ± 0.11) without any overlap; however, they were overlapped with those of ordinary leiomyomas and cellular leiomyomas. In addition to morphological features on nonenhanced and postcontrast MR sequences, DW imaging and ADC measurement may have a potential ability to differentiate uterine sarcomas from benign leiomyomas.

Keywords

Uterus Magnetic resonance Neoplasm Apparent diffusion coefficient Myometrium 

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Copyright information

© European Society of Radiology 2007

Authors and Affiliations

  • Ken Tamai
    • 1
  • Takashi Koyama
    • 2
    Email author
  • Tsuneo Saga
    • 1
  • Nobuko Morisawa
    • 1
  • Koji Fujimoto
    • 1
  • Yoshiki Mikami
    • 3
  • Kaori Togashi
    • 1
  1. 1.Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of MedicineKyoto UniversityKyotoJapan
  2. 2.Department of RadiologyKyoto University HospitalKyotoJapan
  3. 3.Laboratory of Anatomic PathologyKyoto University HospitalKyotoJapan

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