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Energetic differences between viable and non-viable myocardium in patients with recent myocardial infarction are not an effect of differences in wall thinning— a multivoxel 31P-MR-spectroscopy and MRI study

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Abstract

To evaluate multivoxel 31P-MR spectroscopy (MRS) for assessment of energy metabolism in patients with myocardial infarction (MI) in correlation to left ventricular (LV) wall thickness and the outcome of revascularization. Thirty patients with subacute anterior myocardial infarction and planned revascularization were enrolled. 3D–chemical shift imaging was applied to determine PCr/ATP ratios in two areas: infarcted/anterior and noninfarcted/septal myocardium. MRI was used to evaluate LV function and wall thickness, and was repeated 6 months after revascularization to assess myocardial viability. Fifteen volunteers were controls. Fifteen patients showed normalization of wall motion abnormalities after revascularization (Group 1; viable), 15 not (Group 2; non-viable). Regarding infarcted/anterior myocardium, Group 2 had lower PCr/ATP ratios (0.81 ± 0.60 vs 1.17 ± 0.25), and PCr/ATP ratios were reduced in both groups compared to controls (1.45 ± 0.29). Regarding noninfarcted/septal myocardium, again Group 2 had lower ratios (0.93 ± 0.53 vs 1.31 ± 0.38); however, compared to controls (1.51 ± 0.32) a reduction of PCr/ATP ratios was only found in Group 2. For both myocardial regions, no correlations between PCr/ATP ratios and LV wall thickness were detected. The more severe energetic alteration in irreversibly damaged myocardium is not an effect of differences of wall thinning. Additional alterations of noninfarcted, adjacent myocardium can be detected.

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Acknowledgements

The authors thank Alexandra Kenn for her excellent technical assistance in our MR-imaging and MRS studies. The study was supported by a grant from the Interdisziplinäres Zentrum für Klinische Forschung, Universität Würzburg, part F12 (01 KS 9603).

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Authors and Affiliations

  1. Institut für Röntgendiagnostik, Universität Würzburg, Josef-Schneider-Straße 2, 97080, Würzburg, Germany

    Meinrad Beer, Wolfram Machann, Jörn Sandstede, Stefan Buchner, Claudia Lipke, Herbert Köstler & Dietbert Hahn

  2. Klinik und Poliklinik für Nuklearmedizin, Universität Würzburg, Josef-Schneider-Strasse 2, Würzburg, Germany

    Reinhard Lorenz

  3. Medizinische Klinik, Universität Würzburg, Josef-Schneider-Strasse 2, Würzburg, Germany

    Kerstin Harre & Matthias Spindler

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  1. Meinrad Beer
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Correspondence to Meinrad Beer.

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Beer, M., Machann, W., Sandstede, J. et al. Energetic differences between viable and non-viable myocardium in patients with recent myocardial infarction are not an effect of differences in wall thinning— a multivoxel 31P-MR-spectroscopy and MRI study. Eur Radiol 17, 1275–1283 (2007). https://doi.org/10.1007/s00330-006-0492-y

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  • DOI: https://doi.org/10.1007/s00330-006-0492-y

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