Advertisement

European Radiology

, Volume 17, Issue 1, pp 49–60 | Cite as

Retinoblastoma—MR appearance using a surface coil in comparison with histopathological results

  • Arne-Jörn LemkeEmail author
  • Iris Kazi
  • Ulrike Mergner
  • Paul Ivan Foerster
  • Heinrich Heimann
  • Nikolaos Bechrakis
  • Andreas Schüler
  • Marie-Isabell Senfft von Pilsach
  • Michael Foerster
  • Roland Felix
  • Norbert Hosten
Neuro

Abstract

Purpose

The purpose of this work was to evaluate the characteristic appearance of untreated retinoblastoma on a large sample in comparison to the histological findings after therapeutical enucleation.

Materials and methods

In a prospective clinical trial 46 children with retinoblastoma in 63 affected untreated eyes were examined under general anesthesia on MRI using a 1.5-T system. The examinations were performed with a special surface coil applying an examination protocol including fast T2- and T1-weighted spin echo sequences and additional fast T1-WI after intravenous injection of Gd-DTPA in different planes. The imaging results were compared to the histopathological findings in 29 patients with 30 affected eyes.

Results

Comparing MRI findings and histopathological results, optic nerve infiltration was detected with a sensitivity of 53.8% and a specificity of 82.3% on MRI, infiltration of the choroid with a sensitivity of 75.0% and a specificity of 100.0%, and the degree of tumor calcification with a sensitivity of 91.7% and a specificity of 88.9%. In this study the characteristic MR appearance of untreated retinoblastoma was evaluated.

Conclusion

MRI was helpful in relevant aspects of pretherapeutical retinoblastoma staging, deficits remain regarding optic nerve infiltration.

Keywords

MRI Retinoblastoma Surface coil Eye tumors Eye Orbit 

Notes

Acknowledgements

This work was supported by a grant from the Deutsche Forschungsgemeinschaft Graduiertenkolleg 331 “Temperaturabhängige Effekte in Therapie und Diagnostik”.

This work was supported by grant “Intraokulare Geschwülste im Kindes- und Erwachsenenalter: 3D-Bestrahlungsplanung mit der hochauflösenden Magnetresonanztomographie” from Deutsche Krebshilfe.

This work was supported by grant “Magnetresonanztomographische Tumordiagnostik unter Einsatz eines schnellen Gradientensystems” from Deutsche Krebshilfe.

This work is part of the thesis of Ulrike Mergner.

References

  1. 1.
    Francois J (1979) Costenbader Memorial Lecture: Genesis and genetics of retinoblastoma. Adv Ophthalmol 39:181–209PubMedGoogle Scholar
  2. 2.
    Abramson DH, Frank CM, Susman M et al (1998) Presenting signs of retinoblastoma. J Pediatr 132:505–508PubMedCrossRefGoogle Scholar
  3. 3.
    Schüler AO, Bornfeld N (2000) Current therapy aspects of intraocular tumors. Ophthalmologe 97:207–222PubMedCrossRefGoogle Scholar
  4. 4.
    Schüler AO, Hosten N, Bechrakis NE et al (2003) High resolution magnetic resonance imaging of retinoblastoma. Br J Ophthalmol 87:330–335CrossRefGoogle Scholar
  5. 5.
    Beets-Tan RG, Hendriks MJ, Ramos LM et al (1994) Retinoblastoma: CT and MRI. Neuroradiology 36:59–62PubMedCrossRefGoogle Scholar
  6. 6.
    Wilms G, Dralands G, Van Fraeyenhoven L et al (1989) Magnetic resonance imaging in lesions of the eye globe. J Belge Radiol 72:165–172PubMedGoogle Scholar
  7. 7.
    Galluzzi P, Cerase A, Hadjistilianou T et al (2003) Retinoblastoma: Abnormal gadolinium enhancement of anterior segment of eyes at MR imaging with clinical and histopathologic correlation. Radiology 228:683–690PubMedCrossRefGoogle Scholar
  8. 8.
    Mafee MF, Goldberg MF, Greenwald MJ et al (1987) Retinoblastoma and simulating lesions: role of CT and MR imaging. Radiol Clin North Am 25:667–682PubMedGoogle Scholar
  9. 9.
    Haik BG, Saint Louis L, Smith ME et al (1985) Magnetic resonance imaging in the evaluation of leukocoria. Ophthalmology 92:1143–1152PubMedGoogle Scholar
  10. 10.
    Mafee MF, Goldberg MF, Cohen SB et al (1989) Magnetic resonance imaging versus computed tomography of leukocoric eyes and use of in vitro proton magnetic resonance spectroscopy of retinoblastoma. Ophthalmology 96:965–975PubMedGoogle Scholar
  11. 11.
    Peyster RG, Augsburger JJ, Shields JA et al (1988) Intraocular tumors: evaluation with MR imaging. Radiology 168:773–779PubMedGoogle Scholar
  12. 12.
    Char DH, Hedges TR, Norman D (1984) Retinoblastoma. CT diagnosis. Ophthalmology 91:1347–1350PubMedGoogle Scholar
  13. 13.
    Lindahl S (1986) Computed tomography of retinoblastoma. Acta Radiol Diagn Stockh 27:513–518PubMedGoogle Scholar
  14. 14.
    Taktikos A (1966) Investigation of retinoblastoma with special reference to histology and prognosis. Br J Ophthalmol 50:225–234PubMedCrossRefGoogle Scholar
  15. 15.
    Shields CL, Shields JA, Baez K et al (1994) Optic nerve invasion of retinoblastoma. Metastatic potential and clinical risk factors. Cancer 73:692–698PubMedCrossRefGoogle Scholar
  16. 16.
    Messmer EP, Heinrich T, Hopping W et al (1991) Risk factors for metastases in patients with retinoblastoma. Ophthalmology 98:136–141PubMedGoogle Scholar
  17. 17.
    Kopelman JE, McLean IW, Rosenberg SH (1987) Multivariate analysis of risk factors for metastasis in retinoblastoma treated by enucleation. Ophthalmology 94:371–377PubMedGoogle Scholar
  18. 18.
    John-Mikolajewski V, Messmer E, Sauerwein W et al (1987) Orbital computed tomography. Does it help in diagnosing the infiltration of choroid, sclera and/or optic nerve in retinoblastoma? Ophthalmic Paediatr Genet 8:101–104PubMedGoogle Scholar
  19. 19.
    Jacquemin C, Karcioglu ZA (1998) Detection of optic nerve involvement in retinoblastoma with enhanced computed tomography. Eye 12:179–183PubMedGoogle Scholar
  20. 20.
    Hosten N, Lemke AJ (1997) A special surface coil for high-resolution ocular MRI. Front Radiat Ther Oncol 30:20–25PubMedGoogle Scholar
  21. 21.
    Balmer A, Munier F, Uffer S (1998) Diagnostic imaging of intraocular lesions in the child. Klin Monatsbl Augenheilkd 212:252–256PubMedCrossRefGoogle Scholar
  22. 22.
    Ainbinder DJ, Haik BG, Frei DF et al (1996) Gadolinium enhancement: improved MRI detection of retinoblastoma extension into the optic nerve. Neuroradiology 38:778–781PubMedCrossRefGoogle Scholar
  23. 23.
    de Graaf P, Barkhof F, Moll AC et al (2005) Retinoblastoma: MR imaging parameters in detection of tumor extent. Radiology 235:197–207PubMedCrossRefGoogle Scholar
  24. 24.
    Shields CL, Shields JA, Baez KA et al (1993) Choroidal invasion of retinoblastoma: metastatic potential and clinical risk factors. Br J Ophthalmol 77:544–548PubMedCrossRefGoogle Scholar
  25. 25.
    Barkhof F, Smeets M, van der Valk P et al (1997) MR imaging in retinoblastoma. Eur Radiol 7:726–731PubMedGoogle Scholar
  26. 26.
    Potter PD, Shields CL, Shields JA et al (1996) The role of magnetic resonance imaging in children with intraocular tumors and simulating lesions. Ophthalmology 103:1774–1783PubMedGoogle Scholar
  27. 27.
    Hosten N, Bornfeld N, Wassmuth R et al (1997) Uveal melanoma: detection of extraocular growth with MR imaging and US. Radiology 202:61–67PubMedGoogle Scholar
  28. 28.
    Davis PC, Newman NJ (1996) Advances in neuroimaging of the visual pathways. Am J Ophthalmol 121:690–705PubMedGoogle Scholar
  29. 29.
    Shields JA, Leonard BC, Michelson JB et al (1976) B-scan ultrasonography in the diagnosis of atypical retinoblastomas. Can J Ophthalmol 11:42–51PubMedGoogle Scholar
  30. 30.
    Weber AL, Mafee MF (1992) Evaluation of the globe using computed tomography and magnetic resonance imaging. Isr J Med Sci 28:145–152PubMedGoogle Scholar
  31. 31.
    Mafee MF, Putterman A, Valvassori GE et al (1987) Orbital space-occupying lesions: role of computed tomography and magnetic resonance imaging. An analysis of 145 cases. Radiol Clin North Am 25:529–559PubMedGoogle Scholar
  32. 32.
    Nucci P, Modorati G, Pierro L et al (1989) Comparative evaluation of echography and C.A.T. in diagnosing retinoblastoma. Minerva Pediatr 41:129–131PubMedGoogle Scholar
  33. 33.
    Gizewski ER, Wanke I, Jurklies C et al (2005) T1 Gd-enhanced compared with CISS sequences in retinoblastoma: superiority of T1 sequences in evaluation of tumour extension. Neuroradiology 47:56–61PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Arne-Jörn Lemke
    • 1
    Email author
  • Iris Kazi
    • 1
  • Ulrike Mergner
    • 1
  • Paul Ivan Foerster
    • 2
  • Heinrich Heimann
    • 3
  • Nikolaos Bechrakis
    • 3
  • Andreas Schüler
    • 4
  • Marie-Isabell Senfft von Pilsach
    • 1
  • Michael Foerster
    • 3
  • Roland Felix
    • 1
  • Norbert Hosten
    • 5
  1. 1.Charité, Universitätsmedizin BerlinCampus Virchow-KlinikumBerlinGermany
  2. 2.Klinikum der Universität München-InnenstadtUniversitätsaugenklinikMünchenGermany
  3. 3.Charité, Universitätsmedizin BerlinCampus Benjamin-FranklinBerlinGermany
  4. 4.Universitätsaugenklinik EssenEssenGermany
  5. 5.Klinikum der Ernst-Moritz-Arndt-Universitäts GreifswaldInstitut für Diagnostische Radiologie und NeuroradiologieGreifswaldGermany

Personalised recommendations