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Disseminated dendriform pulmonary ossification associated with usual interstitial pneumonia: incidence and thin-section CT–pathologic correlation

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The aim of this work was to assess the incidence of disseminated pulmonary dendriform ossification in usual interstitial pneumonia and nonspecific interstitial pneumonia, and to correlate thin-section computed tomography (CT) and histopathologic findings. We retrospectively reviewed thin-section CT and pathologic specimens of biopsy-proven usual interstitial pneumonia (75 patients, 57 men and 18 women, mean age 60 years, range 29–83 years) and nonspecific interstitial pneumonia (44 patients, 9 men and 35 women, mean age 55 years, range 20–73 years). On review of CT and histopathologic specimens, diffuse dendriform ossification was identified in five (four men and one woman, age range 41–68 years, mean 58 years) of 75 patients (6.7%) with usual interstitial pneumonia. It was not seen in any of 44 patients with nonspecific interstitial pneumonia. With thin-section CT (osteoporosis window; window width 818, level 273), disseminated dendriform pulmonary ossification was detected as multiple tiny calcifications in bibasilar subpleural lungs (100% sensitive and 100% specific when compared with histopathologic findings as the gold standard). The thin-section CT finding of multiple tiny calcifications in bibasilar subpleural lungs might be of some help in the differential diagnosis between usual interstitial pneumonia and nonspecific interstitial pneumonia, considering they were not seen in any patients with nonspecific interstitial pneumonia (0%, 0/44) in our series.

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  1. Travis WD, Colby TV, Koss MN, Rosado-de-Christenson ML, Muller NL, King TE Jr (2002) Non-neoplastic disorders of the lower respiratory tract. Armed Forces Institute of Pathology, Washington, DC

    Google Scholar 

  2. Mendeloff J (1971) Disseminated nodular pulmonary ossification in the Hamman–Rich lung. Am Rev Respir Dis 103:269–274

    Google Scholar 

  3. Fried ED, Godwin TA (1992) Extensive diffuse pulmonary ossification. Chest 102:1614–1615

    Google Scholar 

  4. Muller KM, Friemann J, Stichnoth E (1980) Dendriform pulmonary ossification. Pathol Res Pract 168:163–172

    Google Scholar 

  5. Ndimbie OK, Williams CR, Lee MW (1987) Dendriform pulmonary ossification. Arch Pathol Lab Med 111:1062–1064

    Google Scholar 

  6. Reinehr M, Rittinger M, Muller-Wening D, Wagner T, Gabelmann A, Moller P, Scheil S (2003) Diffuse pulmonary ossifications with mortal consequences. A case report. Pathologe 24:114–118

    Google Scholar 

  7. Trejo O, Xaubet A, Marin-Arguedas A, Torres A, Ramirez J, Luburich P (2002) Dendriform pulmonary ossification associated with idiopathic pulmonary fibrosis. Arch Bronconeumol 38:399–400

    Google Scholar 

  8. Gevenois PA, Abehsera M, Knoop C, Jacobovitz D, Estenne M (1994) Disseminated pulmonary ossification in end-stage pulmonary fibrosis: CT demonstration. Am J Roentgenol 162:1303–1304

    Google Scholar 

  9. Jaderborg JM, Dunton RF (2001) Rare clinical diagnosis of dendriform pulmonary ossification. Ann Thorac Surg 71:2009–2011

    Google Scholar 

  10. Coric M, Miculinic N, Seiwerth S (1997) Disseminated pulmonary ossification. Case report. Lijec Vjesn 119:324–326

    Google Scholar 

  11. Felson B, Schwarz J, Lukin RR, Hawkins HH (1984) Idiopathic pulmonary ossification. Radiology 153:303–310

    Google Scholar 

  12. Kanne JP, Godwin JD, Takasugi JE, Schmidt RA, Stern EJ (2004) Diffuse pulmonary ossification. J Thorac Imaging 19:98–102

    Google Scholar 

  13. Prokop M, Galanski M (2003) Spiral and multislice computed tomography of the body. Georg Thieme Verlag, New York

    Google Scholar 

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Correspondence to Joungho Han.

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Kim, T.S., Han, J., Chung, M.P. et al. Disseminated dendriform pulmonary ossification associated with usual interstitial pneumonia: incidence and thin-section CT–pathologic correlation. Eur Radiol 15, 1581–1585 (2005).

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