European Radiology

, Volume 15, Issue 5, pp 872–880 | Cite as

Myocardial viability assessment in patients with highly impaired left ventricular function: comparison of delayed enhancement, dobutamine stress MRI, end-diastolic wall thickness, and TI201-SPECT with functional recovery after revascularization

  • M. GutberletEmail author
  • M. Fröhlich
  • S. Mehl
  • H. Amthauer
  • H. Hausmann
  • R. Meyer
  • H. Siniawski
  • J. Ruf
  • M. Plotkin
  • T. Denecke
  • B. Schnackenburg
  • R. Hetzer
  • R. Felix


This study compared different magnetic resonance imaging (MRI) methods with Tl201 single photon emission computerized tomography (SPECT) and the “gold standard” for viability assessment, functional recovery after coronary artery bypass grafting (CABG). Twenty patients (64±7.3 years) with severely impaired left ventricular function (ejection fraction [EF] 28.6±8.7%) underwent MRI and SPECT before and 6 months after CABG. Wall-motion abnormalities were assessed by stress cine MRI using low-dose dobutamine. A segment with a nonreversible defect in Tl201-SPECT and a delayed enhancement (DE) in an area >50% of the entire segment, as well as an end-diastolic wall thickness <6 mm, was defined as nonviable. The mean postoperative EF (n=20) improved slightly from 28.6±8.7% to 32.2±12.4% (not significant). Using the Tl201-SPECT as the reference method, end-diastolic wall thickness, MRI-DE, and stress MRI showed high sensitivity of 94%, 93%, and 84%, respectively, but low specificities. Using the recovery of contractile function 6 months after CABG as the gold standard, MRI-DE showed an even higher sensitivity of 99%, end-diastolic wall thickness 96%, stress MRI 88%, and Tl201-SPECT 86%. MRI-DE showed advantages compared with the widely used Tl201-SPECT and all other MRI methods for predicting myocardial recovery after CABG.


Myocardial viability Gated SPECT Delayed enhancement Dobutamine stress End-diastolic wall thickness 



The study was supported in part by grants from the Deutsche Forschungsgemeinschaft (BO-866/5-1). We thank Dr. Lutz Lüdemann and Dipl. math. Arne Janza for adapting the multimodality software Amira for our purposes. Furthermore, we thank the technicians, Mrs. Sylvia Foelz, Mrs. Virginia Ding-Reinelt, Mrs. Silvia Kurth, and Mrs. Catharina Oledtzki, and the medical editor, Ms. Anne Gale, for their assistance.


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Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • M. Gutberlet
    • 1
    Email author
  • M. Fröhlich
    • 1
  • S. Mehl
    • 1
  • H. Amthauer
    • 1
  • H. Hausmann
    • 2
  • R. Meyer
    • 2
  • H. Siniawski
    • 2
  • J. Ruf
    • 1
  • M. Plotkin
    • 1
  • T. Denecke
    • 1
  • B. Schnackenburg
    • 3
  • R. Hetzer
    • 2
  • R. Felix
    • 1
  1. 1.Charité, Campus Virchow-KlinikumKlinik für Strahlenheilkunde, Diagnostic Radiology and Nuclear MedicineBerlinGermany
  2. 2.German Heart Institute BerlinBerlinGermany
  3. 3.Philips Medical SystemsHamburgGermany

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