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Influence of a dexamethasone-eluting covered stent on tissue reaction: an experimental study in a canine bronchial model

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Abstract

This study was designed to evaluate the feasibility and efficacy of a dexamethasone (DXM)-eluting, covered, self-expanding metallic stent to reduce tissue reaction following stent placement in a canine bronchial model. We placed a DXM-eluting, polyurethane-covered, self-expanding metallic stent (drug stent, DS) and a polyurethane-covered, self-expanding metallic stent (control stent, CS) alternately in each left main bronchus and left lower lobe bronchus in 12 dogs. The stents were 20 mm in diameter and length when fully expanded. The dose of DXM was approximately 36.7 mg in each DS, but was absent in the CS. The dogs were euthanased 1 week (n=4), 2 weeks (n=4) or 4 weeks (n=4) after stent placement. Histologic findings, such as epithelial erosion/ulcer or granulation tissue thickness, were obtained from the mid-portion of the bronchus, where the stent had been placed, and evaluated between DS and CS. There were no procedure-related complications or malpositioning of any of the bronchial stents. Stent migration was detected in one dog just before euthanasia 1 week following stent placement. Stent patency was maintained until euthanasia in all dogs. Epithelial erosion/ulcer (%) was significantly less in the DS (mean±standard deviation, 46.88±23.75) than in the CS (73.75±14.08) (P=0.026) for all time-points. There was a decrease in epithelial erosion/ulcer as the follow-up period increased in both DS and CS. The granulation tissue thickness (mm) was less in DS (2.63±2.05) than in CS (3.49±2.95), although the difference was not significant (P=0.751) for all time-points. There was a tendency toward an increase in granulation tissue thickness and chronic lymphocytic infiltration as the follow-up period increased in both DS and CS. In conclusion, DXM-eluting, covered, self-expanding metallic stent seems to be effective in reducing tissue reaction secondary to stent placement in a canine bronchial model.

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Acknowledgements

The study was supported by a grant (HMP-00-B-31400-00169) from the Highly Advanced National Project, Ministry of Health and Warfare, Republic of Korea.

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Authors and Affiliations

  1. Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, 388-1, Pungnap-2dong, Songpa-gu, Seoul, 138-736, South Korea

    Ji Hoon Shin, Ho-Young Song, Gi Bok Choi, Tae-Hyung Kim & Ji-Yeon Suh

  2. Department of Radiology, Gil Medical Center, Gachon Medical School, 1198, Kuwol-Dong, Namdong-Ku, Inchon, 405-760, South Korea

    Tae-Seok Seo

  3. Department of Polymer Science and Engineering, College of Engineering, Hannam University, Ojeong-dong, Daedeok-gu, Daejeon, 306-791, South Korea

    Soon Hong Yuk

  4. Department of Radiology, Soonchunhyang University Chonan Hospital, 23-20, Bongmyung-dong, Chonan, 330-721, South Korea

    Young-Hwa Kim

  5. Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, 388-1, Pungnap-2dong, Songpa-gu, Seoul, 138-736, South Korea

    Yong-Mee Cho

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  1. Ji Hoon Shin
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Correspondence to Ho-Young Song.

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Shin, J.H., Song, HY., Seo, TS. et al. Influence of a dexamethasone-eluting covered stent on tissue reaction: an experimental study in a canine bronchial model. Eur Radiol 15, 1241–1249 (2005). https://doi.org/10.1007/s00330-004-2564-1

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  • DOI: https://doi.org/10.1007/s00330-004-2564-1

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