Skip to main content

Advertisement

Log in

Synchronous gastrointestinal and musculoskeletal manifestations of different subtypes of inflammatory myofibroblastic tumor: CT, MRI and pathological features

  • Oncology
  • Published:
European Radiology Aims and scope Submit manuscript

Abstract

We describe a case of an unusual multicentric appearance of an inflammatory myofibroblastic tumor, consisting of multiple gastrointestinal masses with different growth patterns and simultaneous, distant, musculoskeletal manifestations. CT and MR imaging features demonstrated a different degree of lesion enhancement, which proved histologically to be related to an alternation of predominantly spindle cell areas with a myxoid-vascular IMT subtype. A clear separation of the imaging characteristics of this tumor’s subtypes by correlation with the pathology was not possible because of the mixed histologic character of the tumor in all its locations. However, MRI signal in the T2-weighted sequence was lower in the spindle cell variant localized predominantly in the musculoskeletal system, while the gastrointestinal predominantly myxoid-vascular counterparts showed slightly higher signal in the T2-weighted sequence.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others

References

  1. Coffin CM, Watterson J, Preist JR et al (1995) Extrapulmonary inflammatory myofibroblastic tumor (inflammatory pseudotumor): a clinicopathologic and immunohistochemical study of 84 cases. Am J Surg Pathol 19:859–871

    CAS  PubMed  Google Scholar 

  2. Mentzel T, Fletcher CDM (1997) The emerging role of myofibroblasts in soft tissue neoplasia. Am J Clin Pathol 107:2–5

    PubMed  Google Scholar 

  3. Majno G (1979) The story of the myofibroblast. Am J Surg Pathol 3:535–542

    CAS  PubMed  Google Scholar 

  4. Gabbiani G, Majno G (1972) Dupuytren’s contracture: fibroblast contracture? An ultrastructural study. Am J Pathol 66:131–143

    CAS  PubMed  Google Scholar 

  5. Meis-Kindblom JM, Enzinger FM (1991) Inflammatory fibrosarcoma of the mesentery and retroperitoneum. A tumor closely simulating inflammatory pseudotumor. Am J Surg Pathol 15:1146–1156

    PubMed  Google Scholar 

  6. Biselli R, Boldrini R, Ferlini C, Boglino C, Inserra A, Bosman C (1999) Myofibroblastic tumors: neoplasias with divergent behaviour. Ultrastructural and flow cytometric analysis. Pathol Res Pract 195:619–632

    CAS  PubMed  Google Scholar 

  7. Dehner LP (1986) Extrapulmonary inflammatory myofibroblastic tumor: the inflammatory pseudotumor as another expression of the fibrohistiocytic complex. Lab Invest 54:15A

    Google Scholar 

  8. Cozzuto C, DeBernardi B, Guarino M et al (1978) Retroperitoneal fibrohistiocytic tumors in children. Cancer 42:1350–1363

    PubMed  Google Scholar 

  9. Kauffman SL, Stout AP (1961) Histiocytic tumors (fibrous xanthoma and histiocytoma) in children. Cancer 14:482–496

    Google Scholar 

  10. Myint MA, Medeiros LJ, Sulaiman RA et al (1994) Inflammatory pseudotumor of the ileum: a report of a multifocal transmural lesion with regional lymph node involvement. Arch Pathol Lab Med 118:1138–1142

    Google Scholar 

  11. Kelekis NK, Warshauer DM, Semelka RC et al (1995) Inflammatory pseudotumor of the liver: appearance on contrast enhanced helical CT and dynamic MR images. J Magn Reson Imaging 5:551–553

    CAS  PubMed  Google Scholar 

  12. Venkataraman S, Semelka RC, Braga L et al (2003) Inflammatory myofibroblastic tumor of the hepatobiliary system: report of MR imaging appearance in four patients. Radiology 227:758–763

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Marius Horger.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Horger, M., Pfannenberg, C., Bitzer, M. et al. Synchronous gastrointestinal and musculoskeletal manifestations of different subtypes of inflammatory myofibroblastic tumor: CT, MRI and pathological features. Eur Radiol 15, 1713–1716 (2005). https://doi.org/10.1007/s00330-004-2453-7

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00330-004-2453-7

Keywords

Navigation