European Radiology

, Volume 15, Issue 5, pp 968–974 | Cite as

Renal MRI findings and their clinical associations in nephropathia epidemica: analysis of quantitative findings

  • A. PaakkalaEmail author
  • P. Dastidar
  • P. Ryymin
  • H. Huhtala
  • J. Mustonen


Morphologic renal magnetic resonance imaging (MRI) findings in patients with nephropathia epidemica (NE) were evaluated, and these findings were correlated with the clinical course of NE. Renal MRI was performed in 20 hospitalized NE patients during the acute phase of their disease. A repeat MRI study was made 5–8 months later. Renal parenchymal volume, renal length and parenchymal thickness were decreased in all patients in the repeat study. Edema/fluid collections were found bilaterally in 16 patients in the primary MRI study. Greater change in parenchymal volume, renal length and parenchymal thickness between the primary and the repeat MRI study as well as the presence of edema/fluid collections in the primary study evinced mild association with clinical fluid volume overload, high blood pressure level, inflammation, thrombocytopenia and severe clinical renal insufficiency. Change in parenchymal volume was associated with a severe clinical course more markedly than the other MRI findings. Measurable renal MRI changes occurred in every NE patient. The severity of the findings in MRI evinced mild association with clinical fluid volume overload, high blood pressure level, inflammation, thrombocytopenia and severe clinical renal insufficiency. Based on this study and our previous ultrasound (US) findings, we prefer US as the primary examination mode in NE patients.


Acute renal failure Hantavirus infection Nephropathia epidemica MRI Renal imaging 



This study was supported financially by the Medical Research Fund of Tampere University Hospital, the Research Fund of Tampere University, the Radiological Society of Finland, the Research Fund of Tampere City, and the Finnish Kidney Foundation and European Commission Project “Diagnostics and control of rodent-borne viral zoonoses in Europe” (QLK2-CT-2002-01358).


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Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • A. Paakkala
    • 1
    • 2
    Email author
  • P. Dastidar
    • 2
  • P. Ryymin
    • 2
  • H. Huhtala
    • 3
  • J. Mustonen
    • 1
    • 4
  1. 1.Medical SchoolUniversity of TampereTampereFinland
  2. 2.Department of RadiologyTampere University HospitalTampereFinland
  3. 3.School of Public HealthUniversity of TampereTampereFinland
  4. 4.Department of MedicineTampere University HospitalTampereFinland

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