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European Radiology

, Volume 14, Issue 2, pp 309–317 | Cite as

Can pre-operative contrast-enhanced dynamic MR imaging for prostate cancer predict microvessel density in prostatectomy specimens?

  • Heinz-Peter SchlemmerEmail author
  • Jonas Merkle
  • Rainer Grobholz
  • Tim Jaeger
  • Maurice Stephan Michel
  • Axel Werner
  • Jan Rabe
  • Gerhard van Kaick
Urogenital

Abstract

The aim of this study was to correlate quantitative dynamic contrast-enhanced MRI (DCE MRI) parameters with microvessel density (MVD) in prostate carcinoma. Twenty-eight patients with biopsy-proven prostate carcinoma were examined by endorectal MRI including multiplanar T2- and T1-weighted spin-echo and dynamic T1-weighted turbo-FLASH MRI during and after intravenous Gd-DTPA administration. Microvessels were stained on surgical specimens using a CD31 monoclonal antibody. The MVD was quantified in hot spots by counting (MVC) and determining the area fraction by morphometry (MVAF). The DCE MRI data were analyzed using an open pharmacokinetic two-compartment model. In corresponding anatomic locations the time shift (Δt) between the beginning of signal enhancement of cancer and adjacent normal prostatic tissue, the degree of contrast enhancement and the contrast exchange rate constant (k21) were calculated. The MVC and MVAF were elevated in carcinoma (p<0.001 and p=0.002, respectively) and correlated to k21 (r=0.62, p<0.001 and r=0.80, p<0.001, respectively). k21-values of carcinoma were significantly higher compared with normal peripheral but not central zone tissue. Δt was longer in high compared with low-grade tumors (p=0.025). The DCE MRI can provide important information about individual MVD in prostate cancer, which may be helpful for guiding biopsy and assessing individual prognosis.

Keywords

Prostate carcinoma Dynamic contrast-enhanced MR imaging Angiogenesis Microvessel density 

Notes

Acknowledgements

We are grateful to M. Späth and A. Kappeler for technical assistance.

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Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • Heinz-Peter Schlemmer
    • 1
    • 5
    Email author
  • Jonas Merkle
    • 1
  • Rainer Grobholz
    • 2
  • Tim Jaeger
    • 3
  • Maurice Stephan Michel
    • 3
  • Axel Werner
    • 4
  • Jan Rabe
    • 4
  • Gerhard van Kaick
    • 1
  1. 1.Department of Oncological Diagnostics and Therapy, German Cancer Research Center, University Hospital MannheimHeidelbergGermany
  2. 2.Department of Pathology, University Hospital MannheimRuprecht Karls UniversityHeidelbergGermany
  3. 3.Department of Urology, University Hospital MannheimRuprecht Karls UniversityHeidelbergGermany
  4. 4.Department of Diagnostic Radiology, University Hospital MannheimRuprecht Karls UniversityHeidelbergGermany
  5. 5.Department of Diagnostic RadiologyUniversity Hospital TuebingenTuebingenGermany

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