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Diverse role of γ-aminobutyric acid in dynamic plant cell responses

Plant Cell Reports volume 38, pages 847–867 (2019)Cite this article

Abstract

Gamma-aminobutyric acid (GABA), a four-carbon non-protein amino acid, is found in most prokaryotic and eukaryotic organisms. Although, ample research into GABA has occurred in mammals as it is a major inhibitory neurotransmitter; in plants, a role for GABA has often been suggested as a metabolite that changes under stress rather than as a signal, as no receptor or motif for GABA binding was identified until recently and many aspects of its biological function (ranging from perception to function) remain to be answered. In this review, flexible properties of GABA in regulation of plant responses to various environmental biotic and abiotic stresses and its integration in plant growth and development either as a metabolite or a signaling molecule are discussed. We have elaborated on the role of GABA in stress adaptation (i.e., salinity, hypoxia/anoxia, drought, temperature, heavy metals, plant–insect interplay and ROS-related responses) and its contribution in non-stress-related biological pathways (i.e., involvement in plant–microbe interaction, contribution to the carbon and nitrogen metabolism and governing of signal transduction pathways). This review aims to represent the multifunctional contribution of GABA in various biological and physiological mechanisms under stress conditions; the objective is to review the current state of knowledge about GABA role beyond stress-related responses. Our effort is to place findings about GABA in an organized and broader context to highlight its shared metabolic and biologic functions in plants under variable conditions. This will provide potential modes of GABA crosstalk in dynamic plant cell responses.

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Acknowledgements

Financial support from Iran National Science Foundation (INSF) Grant number 97007583 to Dr. Maryam Seifi-kalhor is gratefully acknowledged. Authors also want to sincerely thank Hannah Burkett and Sunita Ramesh for critical revising of the manuscript.

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Affiliations

  1. Department of Plant Biology, Center of Excellence in Phylogeny of Living Organisms in Iran, School of Biology, College of Science, University of Tehran, Tehran, 14155, Iran

    Maryam Seifikalhor & Vahid Niknam

  2. Department of Horticulture, College of Aburaihan, University of Tehran, Tehran, Iran

    Sasan Aliniaeifard

  3. Department of Plant Sciences, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran

    Batool Hassani

  4. Bashkir Research Institute of Agriculture, Russian Academy of Sciences, Ufa, Russia

    Oksana Lastochkina

  5. Institute of Biochemistry and Genetics, Russian Academy of Sciences, Ufa, Russia

    Oksana Lastochkina

Authors
  1. Maryam Seifikalhor
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  2. Sasan Aliniaeifard
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  3. Batool Hassani
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  4. Vahid Niknam
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  5. Oksana Lastochkina
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Corresponding author

Correspondence to Sasan Aliniaeifard.

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Seifikalhor, M., Aliniaeifard, S., Hassani, B. et al. Diverse role of γ-aminobutyric acid in dynamic plant cell responses. Plant Cell Rep 38, 847–867 (2019). https://doi.org/10.1007/s00299-019-02396-z

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  • DOI: https://doi.org/10.1007/s00299-019-02396-z

Keywords

  • Abiotic stress
  • Biotic stress
  • GABA
  • Multifunctional contribution
  • Non-stress
  • Plants