Advertisement

Rheumatology International

, Volume 18, Issue 5–6, pp 171–176 | Cite as

Agalactosyl IgG is elevated in patients with active spondyloarthropathy

  • M. Leirisalo-Repo
  • H. E. Hernandez-Munoz
  • G. A. W. Rook
ORIGINAL ARTICLE

Abstract

Patients with rheumatoid arthritis or with Crohn's disease have deficient galactosylation of serum IgG [Gal(0)]. To study whether such deviation occurs in patients with spondyloarthropathy (SPA), we studied the percentage incidence of Gal(0) corrected for age [Gal(0)corr] in 47 SPA patients undergoing ileocolonoscopy and correlated the findings with clinical variables and prognosis of the patients. Gal(0)corr was elevated in 36% of the patients. Such patients had a higher number of inflamed joints (P<0.02), higher ESR (P<0.001) and CRP (P<0.001). Elevated Gal(0)corr was also of prognostic significance: at 6-month follow-up those with elevated levels had a higher number of inflamed joints (P<0.02) and ESR (P<0.05). The presence of high Gal(0)corr did not associate with gut inflammation. In conclusion, a proportion of SPA patients has elevated levels of Gal(0), the amount of which correlates with severity of the disease and is a prognostic marker for chronicity of the disease.

Key words Agalactosylated IgG Spondyloarthropathy Reactive arthritis Ankylosing spondylitis 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • M. Leirisalo-Repo
    • 1
  • H. E. Hernandez-Munoz
    • 2
  • G. A. W. Rook
    • 2
  1. 1.Division of Rheumatology, Department of Medicine, Helsinki University Central Hospital, PO Box 342, FIN-00029 Hyks, Finland e-mail: leirisal@helsinki.fi Fax: +358-9-4714013FI
  2. 2.Department of Bacteriology, UCL Medical School, London, UKGB

Personalised recommendations