Rheumatology International

, Volume 18, Issue 2, pp 59–62 | Cite as

Management of cutaneous lupus erythematosus with low-dose methotrexate: indication for modulation of inflammatory mechanisms

  • I. B. Boehm
  • G. A. Boehm
  • R. Bauer


There is no consensus about an effective and safe treatment for patients with cutaneous lupus erythematosus (LE) who are refractory to antimalarials and/or low-dose oral glucocorticosteroids. Therefore, we retrospectively analyzed the clinical data and laboratory findings of 12 patients who received weekly administrations of 10–25 mg methotrexate (MTX). Previous treatment with antimalarials and/or glucocorticosteroids was not effective or had to be withdrawn because of side effects. Of 12 patients, ten showed improvement of their skin lesions; two patients did not respond to low-dose MTX; two patients cleared rapidly, and five other patients had long-lasting remissions of 5–24 months after stopping MTX treatment. A reduction of circulating autoantibodies was detected in five patients. In all patients, MTX was well tolerated subjectively and objectively. Weekly low-dose MTX is useful for the treatment of cutaneous LE, particularly in those cases which need long-term treatment and/or do not respond to standard therapeutic regimens.

Key words Cutaneous lupus erythematosus Immunomodulatory activity Low-dose methotrexate 


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Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • I. B. Boehm
    • 1
  • G. A. Boehm
    • 2
  • R. Bauer
    • 3
  1. 1.Department of Dermatology, University of Bonn, Sigmund-Freud Strasse 25, D-53105 Bonn, Germany Fax: 49-228-2874333DE
  2. 2.Department of Chemistry, Joseph Black Building, King's Buildings, The University of Edinburgh, West Mains Road, Edinburgh EH9 3JJ, Scotland, UKGB
  3. 3.Department of Dermatology, University of Bonn, Sigmund-Freud Strasse 25, 53105 Bonn, GermanyDE

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