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Rheumatology International

, Volume 18, Issue 2, pp 41–43 | Cite as

Nitric oxide synthesis is increased in patients with systemic lupus erythematosus

  • A. Wanchu
  • M. Khullar
  • S. D. Deodhar
  • P. Bambery
  • A. Sud
ORIGINAL ARTICLE

Abstract

Nitric oxide (NO) is believed to have a role in the inflammatory process. NO production was measured in 26 patients with systemic lupus erythematosus (SLE) and 20 healthy volunteers, using spectrophotometrically determined serum nitrite and citrulline as surrogate markers. Both nitrite and citrulline levels were significantly higher in patients with SLE than in controls (P<0.001). Twelve and 10 patients, respectively, with SLE had nitrite and citrulline levels that were two standard deviations higher than the mean level of controls. These patients had a significantly higher measure of disease activity (SLE Disease Activity Index). These data show that there is increased NO production in SLE and that it may serve as a marker for disease activity.

Key words Citrulline Disease activity Nitrite Nitric oxide Systemic lupus erythematosus 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • A. Wanchu
    • 1
  • M. Khullar
    • 2
  • S. D. Deodhar
    • 1
  • P. Bambery
    • 1
  • A. Sud
    • 1
  1. 1.Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh – 160012, India Tel.: 0172-541032 Ext 231 Fax: 0172-540401IN
  2. 2.Department of Experimental Medicine and Biotechnology, Postgraduate Institute of Medical Education and Research, Chandigarh, IndiaIN

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