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Rheumatology International

, Volume 20, Issue 4, pp 163–166 | Cite as

Acute inflammatory myopathy with severe subcutaneous edema, a new variant? Report of two cases and review of the literature

  •  O. Gorelik
  •  D. Almoznino-Sarafian
  •  I. Alon
  •  M. Rapoport
  •  G. Goltsman
  •  M. Herbert
  •  D. Modai
  •  N. Cohen
Case Report

Abstract.

Acute inflammatory myopathy with severe subcutaneous edema is extremely rare and has been reported in only a handful of cases. We describe two similar patients presenting with this disorder and generalized rash. Unlike the five previously reported cases, the clinical and histologic features of our two patients are more suggestive of dermatomyositis than polymyositis. Nevertheless, scrutinizing all seven reported patients, a number of specific characteristics could be defined. All patients were adult males. Dysphagia was present in four. In six patients, acute inflammatory myopathy was idiopathic while malignancy was present in one. Two patients died despite intensive therapy, three improved on corticosteroid treatment, and two recovered spontaneously. In all patients, limb involvement with marked subcutaneous edema was present, clinically mimicking deep vein thrombosis in both our patients. The presence of severe subcutaneous edema may be a hallmark of a distinctive variant of acute inflammatory myopathy. More cases are needed to discern subtypes of this general entity and to establish guidelines for treatment and prognosis.

Inflammatory myopathy Acute polymyositis Acute dermatomyositis Subcutaneous edema 

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Copyright information

© Springer-Verlag 2001

Authors and Affiliations

  •  O. Gorelik
    • 1
  •  D. Almoznino-Sarafian
    • 1
  •  I. Alon
    • 1
  •  M. Rapoport
    • 2
  •  G. Goltsman
    • 2
  •  M. Herbert
    • 3
  •  D. Modai
    • 1
  •  N. Cohen
    • 1
  1. 1.Department of Internal Medicine F, Assaf Harofeh Medical Center, Affiliated with Sackler Faculty of Medicine, Tel-Aviv University, Zerifin, Israel
  2. 2.Department of Internal Medicine C, Assaf Harofeh Medical Center, Affiliated with Sackler Faculty of Medicine, Tel-Aviv University, Zerifin, Israel
  3. 3.Pathology Division, Assaf Harofeh Medical Center, Affiliated with Sackler Faculty of Medicine, Tel-Aviv University, Zerifin, Israel

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